Close to a Decade of Decrease in Antimicrobial Usage in Danish Pig Production-Evaluating the Effect of the Yellow Card Scheme
Close to a Decade of Decrease in Antimicrobial Usage in Danish Pig Production-Evaluating the Effect of the Yellow Card Scheme
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DOI：
10.3389/fvets.2020.00109
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发表时间：
2020-03-06
影响因子：
3.2
通讯作者：
Jensen, Vibeke Frokjaer
中科院分区：
文献类型：
--
作者：
Antunes, Ana Carolina Lopes;Jensen, Vibeke Frokjaer
抗微生物药物耐药性病原体的出现和传播引起了人们对兽药中广泛和过度使用抗微生物药物的日益关注。自上世纪90年代以来，丹麦实施了几项减少动物抗微生物药物使用的举措，并于2010年实施了黄牌计划。本研究的目的是通过分析2010年至2017年丹麦猪场每月抗菌药物消费量的时间趋势，调查有关黄牌的立法变化对丹麦养猪场抗菌药物使用的影响。采用带有线性增长成分的动态线性模型对数据进行建模。在整个研究期间评估了负增长成分和显著下降到零以下的畜群百分比（基于95%可信区间）。该分析分别针对每个农场的不同年龄组：断奶仔猪（30公斤以下）、母猪和育肥猪群，并根据黄牌行动（2008-2009年）之前的抗菌素使用情况进行分类，分为“低”、“中等”或“高”消费群。结果表明，丹麦猪群的抗菌素消费量下降，在两个时期更为明显：黄牌的引入和2014年立法的公告和变化。2011年1月，高消费类别的断奶牛群中负增长部分的比例最高，达到82%；2012年10月，中等抗菌药物消费的断奶牛群中负增长部分的比例为71%。中等消费品类的育肥牛负增长比例从2010年1月的38%上升到2011年7月的71%。在2014年立法宣布和修改之后，抗菌素消费量的下降也很明显，特别是对母猪和育肥猪而言。我们的研究结果表明，黄卡计划的变化促进了丹麦猪群中抗菌素使用的持续减少，特别是在抗菌素消费量高的猪群中。
The emergence and dissemination of antimicrobial resistant pathogens have led to rising concern about the widespread and excessive use of antimicrobials in veterinary medicine. Denmark has implemented several initiatives to reduce antimicrobial use in animals since the 90s, with the Yellow Card scheme implemented in 2010. The aim of the present study is to investigate the effects on antimicrobial use in Danish pig farms of changes in the legislation regarding the Yellow Card, based on analysis of temporal trends in monthly antimicrobial consumption calculated at herd-level from 2010 to 2017. A dynamic linear model with a linear growth component was used to model the data. The percentage of herds with a negative growth component and a significant decline below zero (based on 95% credible intervals) was assessed for the entire study period. The analysis was run separately for the different age groups within each farm: weaners (up to 30 kg), sows and finishers herds, and categorized according to antimicrobial use before the Yellow Card initiative (2008-2009), as groups of herds with "low," "moderate," or "high" consumption. The results evidence a decline of the antimicrobial consumption in Danish pig herds, more pronounced during two periods: with the introduction of the Yellow Card and in relation to the announcements and changes in the legislation in 2014. Weaner herds in the high consumption category had the highest percentage of herds with a negative growth component, reaching 82% of herds in January 2011, followed by weaner herds with moderate antimicrobial consumption reaching 71% of herds in October 2012. For finisher herds in the moderate consumption category, the proportion with a negative growth increased from 38% in January 2010 to 71% in July 2011. A decline in antimicrobial consumption was also evident after announcements and changes in the legislation in 2014, particularly for sows and finishers. Our findings suggest that changes in the Yellow Card scheme promoted a continuous reduction in antimicrobial use in Danish pig herds, particularly in herds with high antimicrobial consumption.