Preformed IgG antibodies against major histocompatibility complex class II antigens are major risk factors for high-grade cellular rejection in recipients of heart transplantation
Preformed IgG antibodies against major histocompatibility complex class II antigens are major risk factors for high-grade cellular rejection in recipients of heart transplantation
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DOI：
10.1161/01.cir.98.8.786
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发表时间：
1998-08-25
期刊：
影响因子：
37.8
通讯作者：
Michler, RE
中科院分区：
文献类型：
--
作者：
Itescu, S;Tung, TC;Michler, RE
与供体淋巴细胞特异性反应的预形成抗HLA抗体与急性血管排斥反应和早期心脏移植物衰竭有关。然而，针对供体组的同种异基因主要组织相容性复合体（MHC）I类或II类抗原的预先形成的抗HLA抗体对心脏移植结果的影响尚未得到广泛研究。方法和结果-研究组由68名在1989年至1996年间接受心脏移植的患者组成，这些患者在移植前存在产生抗HLA抗体的高风险。针对同种异体MHC I类或II类抗原的预形成抗体对早期高级细胞排斥反应的发展和对累积年排斥频率的影响被确定。与对照组相比，左心室辅助装置患者和再次移植候选者的IgG抗MHC LI类抗体（IgG抗II）频率增加相似（P
Background-Preformed anti-HLA antibodies reacting specifically with donor lymphocytes have been associated with acute vascular rejection and early cardiac allograft failure. However, the effect of preformed anti-HLA antibodies directed against allogeneic major histocompatibility complex (MHC) class I or II antigens of a donor panel on heart transplantation outcome has not been extensively studied.Methods and Results-The study group consisted of 68 patients who received cardiac transplants between 1989 and 1996 and who were at high risk for developing anti-HLA antibodies before transplantation. The effect of preformed antibodies against allogeneic MHC class I or class II antigens on the development of early high-grade cellular rejection and on cumulative annual rejection frequency was determined. Both patients with left ventricular assist devices and retransplantation candidates had a similar increase in the frequency of IgG anti-MHC class LI antibodies (IgG anti-II) compared with control subjects (P