Relationship between periodontal disease, tooth loss, and carotid artery plaque - The Oral Infections and Vascular Disease Epidemiology Study (INVEST)
Relationship between periodontal disease, tooth loss, and carotid artery plaque - The Oral Infections and Vascular Disease Epidemiology Study (INVEST)
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DOI：
10.1161/01.str.0000085086.50957.22
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发表时间：
2003-09-01
期刊：
影响因子：
8.3
通讯作者：
Sacco, RL
中科院分区：
文献类型：
--
作者：
Desvarieux, M;Demmer, RT;Sacco, RL
背景和目的慢性感染，包括牙周感染，可能易患心血管疾病。本研究调查牙周病和牙齿脱落与亚临床atherosclerosis. Methods的关系，我们招募了711名受试者，平均年龄为66+/-9岁，没有中风或心肌梗死的历史，在口腔感染和血管疾病流行病学研究。受试者接受了全面的牙周检查，广泛的心血管疾病危险因素的测量，并使用高分辨率B型超声颈动脉扫描。回归模型进行了调整，为传统的风险因素（年龄，性别，吸烟，糖尿病，收缩压，低密度和高密度脂蛋白胆固醇，种族，民族，教育，体育活动）和标记的文化背景，健康的生活方式，和心理健康。牙齿脱落水平与颈动脉斑块患病率之间存在显著相关性。牙齿缺失0 ~ 9颗的人中，46%有颈动脉斑块，而牙齿缺失大于或等于10颗的人中，颈动脉斑块患病率约为60%（P
Background and Purpose-Chronic infections, including periodontal infections, may predispose to cardiovascular disease. The present study investigates the relationship of periodontal disease and tooth loss with subclinical atherosclerosis.Methods-We enrolled 711 subjects with a mean age of 66+/-9 years and no history of stroke or myocardial infarction in the Oral Infections and Vascular Disease Epidemiology Study. Subjects received a comprehensive periodontal examination, extensive in-person cardiovascular disease risk factor measurements, and a carotid scan using high-resolution B-mode ultrasound. Regression models were adjusted for conventional risk factors (age, sex, smoking, diabetes, systolic blood pressure, low- and high-density lipoprotein cholesterol, race-ethnicity, education, physical activity) and markers of cultural background, healthy lifestyle, and psychosocial health.Results-Measures of both current and cumulative periodontitis became more severe as tooth loss increased. A significant association was observed between tooth loss levels and carotid artery plaque prevalence. Among those with 0 to 9 missing teeth, 46% had carotid artery plaque, whereas among those with greater than or equal to 10 missing teeth, carotid artery plaque prevalence was approximate to60% (P