Genotoxicity of glycol ethers.
Genotoxicity of glycol ethers.
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DOI：
10.1289/ehp.845797
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发表时间：
1984-08
影响因子：
10.4
通讯作者：
McGregor DB
中科院分区：
文献类型：
--
作者：
McGregor DB
综述了乙二醇醚的遗传毒理学研究进展。乙二醇单甲醚（EGME）和二甘醚的研究比该系列的其他成员更广泛。大多数结果表明没有潜在的遗传毒性，但某些测试对某些化合物产生了积极的反应。乙二醇单乙醚（EGEE）诱导培养细胞姐妹染色单体交换和染色体畸变。EGME和双lyme均引起小鼠精子头形态改变，雄鼠弱显性致死性突变，雄鼠生育能力明显丧失，但可逆。
The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members of this series. Most results indicate a lack of genotoxic potential, but certain tests have yielded positive responses with certain compounds. Ethylene glycol monoethyl ether (EGEE) induced sister chromatid exchanges and chromosomal aberrations in cultured cells. Both EGME and diglyme induced mouse sperm head morphological changes, male rat weak dominant lethal mutations and marked, but reversible, loss of male rat fertility.