EFFECTS OF GENETIC, EPIGENETIC, AND ENVIRONMENTAL-FACTORS ON TAXOL CONTENT IN TAXUS-BREVIFOLIA AND RELATED SPECIES
EFFECTS OF GENETIC, EPIGENETIC, AND ENVIRONMENTAL-FACTORS ON TAXOL CONTENT IN TAXUS-BREVIFOLIA AND RELATED SPECIES
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DOI：
10.1021/np50082a005
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发表时间：
1992-04-01
影响因子：
5.1
通讯作者：
SNADER, KM
中科院分区：
文献类型：
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作者：
WHEELER, NC;JECH, K;SNADER, KM
紫杉醇是一种很有前途的癌症化疗药物，但其需求量远远超过供应量。 目前，紫杉醇源自太平洋红豆杉（Taxus brevifolia）的树皮，这是一种生长缓慢的常绿小树，原产于美国西北部。 如果要通过植物收获来解决供应问题，则有必要了解红豆杉属中紫杉醇含量变异的遗传和非遗传来源的分布和程度。 对代表短叶红豆杉几个种群和其他红豆杉类群的 200 多棵树进行的紫杉醇、三尖杉宁碱和浆果赤霉素 III 的分析测定表明，(1) 种群和物种之间以及种群内紫杉烷含量存在显着差异，(2) 在大多数研究类群的单棵树的芽中发现了超过报告的短叶红豆杉树皮的紫杉醇水平，以及 (3) 收集样品的季节和处理程序可以影响紫杉烷含量。
The demand for taxol, a promising cancer chemotherapeutic agent, far exceeds supply. Presently, taxol is derived from the bark of the Pacific yew, Taxus brevifolia, a small, slow-growing evergreen tree native to the northwestern United States. Knowledge of the distribution and magnitude of genetic and non-genetic sources of variation in taxol content in the genus Taxus is necessary if supply issues are to be met through plant harvesting. Analytical determinations of taxol, cephalomannine, and baccatin III in more than 200 trees representing several populations of T. brevifolia and other yew taxa indicate that (1) significant variation in taxane content exists among and within populations and species, (2) taxol levels exceeding those reported for T. brevifolia bark were found in shoots of individual trees from most taxa studied, and (3) the season in which samples are collected and handling procedures can influence taxane content.