Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly.
Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly.
复制标题
老年人胃食管出血的非甾体抗炎药和住院治疗。
DOI：
10.1001/archinte.1987.00370090097017
复制
发表时间：
1987
影响因子：
--
通讯作者：
H. Jick
中科院分区：
文献类型：
--
作者：
K. Beard;A. Walker;D. Perera;H. Jick
在西雅图普吉特湾的团体健康合作社，在住院90天内服用非甾体抗炎药（NSAID）处方的64岁以上患者中，因胃或食管出血住院的发生率为4.8次/百万人-天，而在64岁以上非NSAID使用者中，因胃或食管出血住院的发生率为3.4次/百万人-天。NSAID使用者包括那些长期使用这些药物的人以及那些最近使用的人。观察到的比率差异（每百万人日1.3次住院; 95%置信区间，每百万人日-0.2至3.4次住院）与老年人胃食管出血住院频率的任何重大增加不一致。没有单一的NSAID似乎具有特殊的风险。机会和不可控的选择因素可以提供合理的解释之间观察到的用户和非用户的小利率差异。
Hospitalization because of bleeding from the stomach or esophagus occurred 4.8 times per million person-days among persons over 64 years of age who filled a prescription for nonsteroidal anti-inflammatory drugs (NSAIDs) within 90 days of hospitalization, and 3.4 times per million person-days among nonusers of NSAIDs over 64 years of age at the Group Health Cooperative of Puget Sound, Seattle. The NSAID users included those who had used these drugs on a long-term basis as well as those who were recent users only. The observed difference in rates (1.3 hospitalizations per million person-days; 95% confidence interval, -0.2 to 3.4 hospitalizations per million person-days) is incompatible with any major increase in the frequency of hospitalization for gastroesophageal bleeding in the elderly. No single NSAID appeared to carry an exceptional risk. Both chance and uncontrollable selection factors could provide plausible explanations for the small rate differences observed between users and nonusers.