Wound contractions, scar contractures and myofibroblasts: a classical case study.
Wound contractions, scar contractures and myofibroblasts: a classical case study.
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伤口收缩、疤痕挛缩和肌成纤维细胞：经典案例研究。
DOI：
10.1097/00005373-197801000-00003
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
D. Larson
中科院分区：
文献类型：
--
作者：
P. Baur;G. Barratt;H. Linares;M. Dobrkovský;A. J. de la Houssaye;D. Larson
伤口愈合组织的收缩性是一个公认的现象（11）。然而，组织收缩并没有在细胞或组织的基础上得到充分的解释。一些报道暗示，组织的被动真皮成分（如胶原蛋白、弹性蛋白等）的分子重排可能是收缩的原因（15,16），而另一些人则将这种现象归因于细胞活动和/或组织肿胀(2)。Majno等人（14）首次报道了在几种动物模型的伤口愈合组织中存在可收缩的成纤维细胞（肌成纤维细胞）。这些细胞也在多种人体组织中被观察到，包括：肉芽组织（17）、Dupuytren病的腱膜结节(5)、肺泡间隔(8)和增生性疤痕(3)。在下面的案例研究中，肌成纤维细胞与组织收缩特征的发生率和相关性是如此深刻，以至于我们认为这些细胞必须仅仅作为组织（疤痕）收缩的位点。尽管所有的显微照片都取自这个病例，但它们的超微结构特征及其含义与我们研究过的其他烧伤患者相似。
The contractile nature of wound healing tissue is a well recognized phenomenon (11). However, the tissue contraction has not been adequately explained on a cellular or tissue basis. Several reports have implied that molecular rearrangements of passive dermal components of the tissue (ie, collagen, elastin, etc.) may be responsible for the contraction (15, 16) while others have ascribed this phenomenon to cellular activity and/or tissue swelling (2).Majno et al.(14) first reported the presence of contractile fibroblasts (myofibroblasts) in wound healing tis-sues of several animal models. These cells have also been observed in a variety of human tissues including: granulation tissues (17), the aponeurotic nodules of Dupuytren's disease (5), pulmonary alveolar septa (8), and hypertrophic scars (3). In the following case study, the incidence and correlation of myofibroblasts with the contractile features of the tissues were so profound that we feel these cells must be solely implicated as the loci of tissue (scar) contraction. Although all of the micrographs were taken from this single case, their ultrastructural features and their implications are similar to those in other burned patients we have studied.