A time-to-prescription-refill measure of antiretroviral adherence predicted changes in viral load in HIV
A time-to-prescription-refill measure of antiretroviral adherence predicted changes in viral load in HIV
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DOI：
10.1016/j.jclinepi.2004.04.002
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发表时间：
2004-10-01
影响因子：
7.2
通讯作者：
Gross, R
中科院分区：
文献类型：
--
作者：
Grossberg, R;Zhang, YW;Gross, R
目的：本研究的目的是确定一个基于药物的时间来补充抗逆转录病毒疗法adherence.Methods措施的有效性和实用性：我们进行了一项观察性队列研究的110名艾滋病毒感染的受试者在一个稳定的，高活性的抗逆转录病毒治疗方案至少3个月在退伍军人事务部医疗中心在费城，宾夕法尼亚州。与自我报告的依从性指标的0.05 log c/mL（95% CI -0.14-0.25 log c/mL）相比，基于药房的再填充时间定义的依从性每增加10%，病毒载量降低0.12 log c/mL（95%置信区间[CI] 0.01-0.23 log c/mL）。因此，仅再灌装定义的测量值与病毒载量变化具有统计学显著相关性。当依从性被分类为良好（大于或等于85%）与差（
Objective: The goal of this study was to determine the validity and utility of a pharmacy-based time-to-refill measure of antiretroviral therapy adherence.Methods: We performed an observational cohort study of 110 HIV-infected subjects on a stable, highly active antiretroviral regimen for at least 3 months at a Veterans' Affairs Medical Center in Philadelphia, Pennsylvania.Results: The viral load decreased by 0.12 log c/mL (95% confidence interval [CI] 0.01-0.23 log c/mL) for each 10% increase in pharmacy-based time-to-refill defined adherence as compared with 0.05 log c/mL (95% CI -0.14-0.25 log c/mL) for the self-reported adherence measure. Thus, only the refill-defined measure was statistically significantly associated with viral load change. When adherence was classified as good (greater than or equal to85%) versus poor (