MYOCARDITIS OF SYSTEMIC LUPUS-ERYTHEMATOSUS - ASSOCIATION WITH MYOSITIS
MYOCARDITIS OF SYSTEMIC LUPUS-ERYTHEMATOSUS - ASSOCIATION WITH MYOSITIS
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DOI：
10.7326/0003-4819-89-5-619
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发表时间：
1978-01-01
影响因子：
39.2
通讯作者：
STEVENS, MB
中科院分区：
文献类型：
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作者：
BORENSTEIN, DG;FYE, WB;STEVENS, MB
我们分析了5例在系统性红斑狼疮背景下临床上明显的心肌炎患者的相关临床和血清学特征。肌炎和抗体核核糖核蛋白（RNP）都存在。对140例连续的系统性红斑狼疮患者进行回顾性分析，包括这5例中的3例，显示心肌炎与肌炎有高度显著的相关性（P < 0.0005）。在这一小组中RNP抗体的存在没有达到统计学显著性（P ≤ 0.05）。0.10）。1例死亡患者的病理结果显示心肌和骨骼肌中的炎症模式相似，表明可能存在针对横纹肌的全身性炎症过程。尽管抗RNP抗体在这些患者中一致发现，但其意义仍有待确定。
Patients (5) with clinically overt myocarditis in the setting of systemic lupus erythematosus were analyzed in terms of associated clinical and serologic features. Myositis and antibodies to nuclear ribonucleoprotein (RNP) were present in all. A retrospective review in 140 consecutive patients with systemic lupus erythematosus, including 3 of these 5, showed a highly significant association of myocarditis with myositis (P < 0.0005). The presence of antibodies to RNP in this small group did not attain statistical significance (P .ltoreq. 0.10). The pathologic findings in the 1 patient who died showed similar patterns of inflammation in both cardiac and skeletal muscle, suggesting the possibility of a generalized inflammatory process directed against striated muscle. Although anti-RNP antibodies were found uniformly in these patients, their significance remains to be defined.