Establishing and applying nomograms based on the 8th edition of the UICC/AJCC staging system to select patients with nasopharyngeal carcinoma who benefit from induction chemotherapy plus concurrent chemoradiotherapy
Establishing and applying nomograms based on the 8th edition of the UICC/AJCC staging system to select patients with nasopharyngeal carcinoma who benefit from induction chemotherapy plus concurrent chemoradiotherapy
复制标题
基于第8版UICC/AJCC分期系统建立列线图并应用以筛选诱导化疗加同步放化疗获益的鼻咽癌患者
DOI：
10.1016/j.oraloncology.2017.04.015
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发表时间：
2017-06-01
期刊：
影响因子：
4.8
通讯作者：
Ma, Jun
中科院分区：
文献类型：
--
作者：
Xu, Cheng;Chen, Yu-Pei;Ma, Jun
Objectives: The subgroups of patients with nasopharyngeal carcinoma (NPC) who benefit from induction chemotherapy plus concurrent chemoradiotherapy (IC + CCRT) remain unclear.Materials and methods: We established prognostic nomograms for overall survival (OS) and disease-free survival (DFS), and validated the nomograms in 1230 patients with NPC and subgroup of 923 patients with locoregionally advanced NPC (LANPC). Three well-matched risk groups (i.e., low, intermediate and high risk) were created via recursive partitioning and 1-to-1 propensity score matching; IC + CCRT was compared with CCRT in each risk group.Results: Histological type, T category, N category, plasma Epstein-Barr virus deoxyribonucleic acid (and the same factors plus age and neutrophil-lymphocyte ratio) were included in the nomograms for DFS (and OS). Both nomograms had higher c-indexes than the 7th edition staging system in both NPC/LANPC (all P-values
