Gastric chief cells: receptors and signal-transduction mechanisms.
Gastric chief cells: receptors and signal-transduction mechanisms.
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胃主细胞：受体和信号转导机制。
DOI：
10.1016/0016-5085(92)90124-h
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发表时间：
1992
期刊：
影响因子：
29.4
通讯作者：
Raufman,JP
中科院分区：
文献类型：
--
作者：
Raufman,JP
阐明受体和介质调节胃蛋白酶原分泌已经落后于了解的因素，控制胃酸分泌。在过去的十年中，作为在细胞水平上研究胃蛋白酶原分泌控制的体外模型的发展的结果，已经获得了关于主要细胞受体和信号转导机制的许多信息，包括分泌素、血管活性肠多肽、胆碱能激动剂、胃泌素、胆囊收缩素、肽YY和霍乱毒素的受体的鉴定和表征。此外，这些细胞制剂允许促分泌素诱导的变化，在主细胞钙浓度，蛋白激酶C分布，磷酸肌醇和环核苷酸含量进行测量和相关的胃蛋白酶原分泌的变化。本文回顾了这些进展，讨论了不确定性和争议的领域，并指出了未来的调查领域。
Elucidation of receptors and mediators regulating gastric pepsinogen secretion has lagged behind understanding of the factors that control acid secretion. During the past decade, as a consequence of the development of in vitro models for studying the control of pepsinogen secretion at the cellular level, much information about chief cell receptors and signal-transduction mechanisms has been obtained, including the identification and characterization of receptors for secretin, vasoactive intestinal polypeptide, cholinergic agonists, gastrin, cholecystokinin, peptide YY, and cholera toxin. Moreover, these cell preparations have permitted secretagogue-induced changes in chief-cell calcium concentration, protein kinase C distribution, and phophoinositide and cyclic nucleotide content to be measured and related to changes in pepsinogen secretion. This article reviews these advances, discusses areas of uncertainty and controversy, and indicates areas for future investigation.