EFFECTS OF TRACHEAL INSTILLATON OF NATURAL SURFACTANT IN PREMATURE LAMBS .1. CLINICAL AND AUTOPSY FINDINGS
EFFECTS OF TRACHEAL INSTILLATON OF NATURAL SURFACTANT IN PREMATURE LAMBS .1. CLINICAL AND AUTOPSY FINDINGS
复制标题
DOI：
10.1203/00006450-197808000-00008
复制
发表时间：
1978-01-01
影响因子：
3.6
通讯作者：
NOZAKI, M
中科院分区：
文献类型：
--
作者：
ADAMS, FH;TOWERS, B;NOZAKI, M
十对妊娠 118-122 天的双胞胎羔羊在第一次呼吸前通过气管内给予天然表面活性剂或稀释剂。通过使用早产双胞胎羔羊模型，显示出以下结果：在研究期间（2小时）内，天然表面活性剂的滴注产生了100%的存活率，室内空气中的血气稳定；佩戴呼吸器时肺部变得越来越顺应；尸检时肺部通常通气良好；良好的肺压力-容量关系；正常肺表面张力测量；组织学证据表明肺泡扩张良好，腔内有大量游离磷脂，没有上皮损伤，也没有透明膜。将天然表面活性剂气管注入早产羔羊可能会保护肺部免于出现呼吸窘迫综合征的许多特征。
Ten pairs of twin lambs 118-122 days of gestation were given either natural surfactant or diluent endotracheally before the 1st breath. By using the premature twin lamb model, the following was shown: instillation of natural surfactant produced 100% survival for the duration of the study period (2 h), stable blood gases on room air; lungs that became increasingly compliant while on the respirator; generally well aerated lungs at autopsy; good lung pressure-volume relationships; normal lung surface tension measurements; and histologic evidence of good alveolar expansion with large amounts of free intraluminal phospholipid, no epithelial damage and no hyaline membranes. Tracheal instillation of natural surfactant into the premature lamb possibly protects the lungs from developing many features characteristic of the respiratory distress syndrome.