A novel 3D bioprinted flexible and biocompatible hydrogel bioelectronic platform
A novel 3D bioprinted flexible and biocompatible hydrogel bioelectronic platform
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DOI：
10.1016/j.bios.2017.11.039
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发表时间：
2018-04-15
影响因子：
12.6
通讯作者：
Magdassi, Shlomo
中科院分区：
文献类型：
--
作者：
Agarwala, Shweta;Lee, Jia Min;Magdassi, Shlomo
生物电子平台正在获得广泛的关注，因为它们为研究生物物种与电子之间的相互作用提供了一个模板。破译电信号对细胞和组织的影响有望用于治疗恶性组织生长、器官再生和制造新时代的医疗器械。这项工作是朝着这个方向前进的一步，生物材料和电子材料在一个平台上共存，不需要任何后处理。我们使用3D生物打印技术制造了一种独立的、灵活的水凝胶平台。制造过程简单、容易，并提供了一种灵活的方法来打印具有首选形状、大小和空间取向的材料。通过交叉电极和加热线圈的设计，该平台可以量身定做，以打印不同功能的各种电路。利用C2C12小鼠成肌细胞株对打印平台的生物相容性进行了测试。此外，还将正常人真皮成纤维细胞(原代细胞)种植在该平台上，以确定其相容性。
Bioelectronics platforms are gaining widespread attention as they provide a template to study the interactions between biological species and electronics. Decoding the effect of the electrical signals on the cells and tissues holds the promise for treating the malignant tissue growth, regenerating organs and engineering new-age medical devices. This work is a step forward in this direction, where bio- and electronic materials co-exist on one platform without any need for post processing. We fabricate a freestanding and flexible hydrogel based platform using 3D bioprinting. The fabrication process is simple, easy and provides a flexible route to print materials with preferred shapes, size and spatial orientation. Through the design of interdigitated electrodes and heating coil, the platform can be tailored to print various circuits for different functionalities. The biocompatibility of the printed platform is tested using C2C12 murine myoblasts cell line. Furthermore, normal human dermal fibroblasts (primary cells) are also seeded on the platform to ascertain the compatibility.