Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease
Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease
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DOI：
10.1136/heartjnl-2012-302949
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发表时间：
2013-06-01
期刊：
影响因子：
5.7
通讯作者：
Mills, Nicholas L.
中科院分区：
文献类型：
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作者：
Padfield, Gareth J.;Tura-Ceide, Olga;Mills, Nicholas L.
目的探讨急性冠状动脉综合征（ACS）对内皮祖细胞（EPC）数量的影响及其与冠状动脉疾病（CAD）严重程度和临床预后的关系。以阐明其临床相关性。设计和设置在三级转诊心脏病中心进行的前瞻性队列研究。患者200人1例因怀疑心绞痛或ACS而接受冠状动脉造影的患者。主要观察指标通过流式细胞术确定推定的EPC群体。使用Gensini评分系统对CAD进行量化。结果循环中CD 34（+）VEGFR-2（+）和CD 34（+）VEGFR-2（+）CD 133（+）细胞很少（均为0.1）。相比之下，与冠状动脉正常的患者相比，CAD患者的CD 34（+）CD 45（-）细胞增加（p=0.008），并与动脉粥样硬化负荷相关（r=0.44，p
Objective We wished to determine the effect of an acute coronary syndrome (ACS) on putative endothelial progenitor cell (EPC) populations, and define their relationship to coronary artery disease (CAD) severity and clinical outcome, in order to clarify their clinical relevance.Design and setting A prospective cohort study conducted in a tertiary referral cardiac centre.Patients Two-hundred-and-one patients undergoing coronary angiography for suspected angina or ACS.Main outcome measures Putative EPC populations were determined by flow cytometry. CAD was quantified using the Gensini scoring system. Survival free from revascularisation, recurrent myocardial infarction and death were determined at 3 years.Results Circulating CD34(+)VEGFR-2(+) and CD34(+)VEGFR-2(+)CD133(+) cells were rare (0.1 for all). By contrast, CD34(+)CD45(-) cells were increased in patients with CAD compared with those with normal coronary arteries (p=0.008) and correlated with atheroma burden (r=0.44, p