Increased thrombin activity after allergen challenge - A potential link to airway remodeling?
Increased thrombin activity after allergen challenge - A potential link to airway remodeling?
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DOI：
10.1164/rccm.200308-1156oc
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发表时间：
2004-02-01
影响因子：
24.7
通讯作者：
Jarjour, NN
中科院分区：
文献类型：
--
作者：
Terada, M;Kelly, EAB;Jarjour, NN
凝血酶除了在止血中发挥核心作用外，还可能在炎症和重塑中发挥作用。为了研究凝血酶在哮喘变应性气道炎症中的作用，我们采用酶促法测定了19例特应性哮喘患者支气管肺泡灌洗液中凝血酶的活性。凝血酶活性从第1天的0（0,2.9）增加到第2天的41.1 (0.3,75.6)U × 10(-3)/ml (p = 0.002)，并与第2天灌洗液总蛋白水平相关（r = 0.885, p = 0.002）
In addition to its central role in hemostasis, thrombin may play a role in inflammation and remodeling. To investigate the contribution of thrombin to allergic airway inflammation in asthma, we used an enzymatic assay to determine thrombin activity in bronchoalveolar lavage fluid obtained from 19 subjects with atopic asthma before (Day 0) and 48 hours after (Day 2) segmental bronchoprovocation with antigen. Thrombin activity increased from 0 (0, 2.9) on Day 1 to 41.1 (0.3, 75.6) U x 10(-3)/ml on Day 2 (p = 0.002) and correlated with total protein levels in lavage fluid on Day 2 (r = 0.885, p