Dietary patterns and the risk of breast cancer in Japanese women
Dietary patterns and the risk of breast cancer in Japanese women
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DOI：
10.1111/j.1349-7006.2007.00540.x
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发表时间：
2007-09-01
期刊：
影响因子：
5.7
通讯作者：
Tajima, Kazuo
中科院分区：
文献类型：
--
作者：
Hirose, Kaoru;Matsuo, Keitaro;Tajima, Kazuo
日本饮食中可能导致日本女性乳腺癌发病率相对较低的成分尚未详细阐明。为了评估日本人群的广泛饮食模式与乳腺癌风险之间的关联，作者利用爱知癌症中心 (HERPACC) 医院流行病学研究项目的数据进行了一项病例对照研究。因子分析（主要成分）用于根据 31 种食物变量得出食物模式，并指定四种主要饮食模式：谨慎、脂肪、日本和咸味。总共纳入了1885例乳腺癌病例，并招募了22333名女性非癌症患者作为对照组。使用多重逻辑回归分析确定优势比 (OR) 和 95% 置信区间 (95% CI)。在调整潜在的混杂因素后，脂肪、日本或咸的饮食模式与总体乳腺癌风险之间没有明显的关联。相比之下，谨慎饮食之间存在明显的负相关关系。与最低四分位数的女性相比，审慎饮食模式得分最高四分位数的女性患乳腺癌的风险降低了 27%（95% CI：0.63-0.84，趋势 p < 0.0001）。此外，对于体重指数 >= 25 的女性，与最低四分位数相比，脂肪因子评分最高四分位数与乳腺癌风险增加 58% 相关，具有显着的线性趋势 (P = 0.027)。作者发现谨慎的饮食模式与乳腺癌风险呈负相关。此外，脂肪和日本模式可能会增加肥胖女性患乳腺癌的风险。
Components of the Japanese diet that might contribute to the relatively low breast cancer incidence in Japanese women have not been clarified in detail. To evaluate associations between broad dietary patterns and breast cancer risk in a Japanese population, the authors conducted a case-control study using data from the hospital-based epidemiologic research program at Aichi Cancer Center (HERPACC). Factor analysis (principal components) was used to derive food patterns based on the 31 food variables and allowed designation of four major dietary patterns: prudent, fatty, Japanese and salty. In total, 1885 breast cancer cases were included and 22 333 female non-cancer patients were recruited as the control group. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined using multiple logistic regression analysis. After adjusting for potential confounders, there were no clear associations between the fatty, Japanese or salty dietary patterns and overall breast cancer risk. In contrast, an inverse association was evident for the prudent dietary. Women in the highest quartile of the prudent dietary pattern scores, had a 27% decreased risk of breast cancer compared with those in the lowest (95% CI: 0.63-0.84, p for trend < 0.0001). In addition, for women with a body mass index >= 25, the highest quartile of the fatty factor score was associated with a 58% increment in breast cancer risk compared to the lowest quartile, with a significant linear trend (P = 0.027). The authors found the prudent dietary pattern to be negatively associated with breast cancer risk. In addition, the fatty and Japanese patterns may increase breast cancer risk among obese women.