Bioengineering of a human whole tooth: progress and challenge.
Bioengineering of a human whole tooth: progress and challenge.
复制标题
人类全牙生物工程：进展与挑战。
DOI：
10.1186/2045-9769-3-8
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Zhang Y;Chen Y
基于干细胞的可植入人类牙齿生物工程的主要挑战是鉴定合适的出生后干细胞来源，所述出生后干细胞由于成年牙齿中缺乏釉质上皮细胞而具有成牙能力作为上皮成分。在最近一期（2013，2：6）的Cell Regeneration中，Cai及其同事报告说，来自人类诱导多能干细胞（iPSCs）的上皮片可以在功能上替代牙胚上皮细胞再生牙齿样结构，为未来的人类牙齿再生提供了有吸引力的干细胞来源。
A major challenge in stem cell-based bioengineering of an implantable human tooth is to identify appropriate sources of postnatal stem cells that are odontogenic competent as the epithelial component due to the lack of enamel epithelial cells in adult teeth. In a recent issue (2013, 2:6) of Cell Regeneration, Cai and colleagues reported that epithelial sheets derived from human induced pluripotent stem cells (iPSCs) can functionally substitute for tooth germ epithelium to regenerate tooth-like structures, providing an appealing stem cell source for future human tooth regeneration.