Airway eosinophilia is not a requirement for allergen‐induced airway hyperresponsiveness
Airway eosinophilia is not a requirement for allergen‐induced airway hyperresponsiveness
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DOI：
10.1046/j.1365-2222.2000.00772.x
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发表时间：
2000-01
影响因子：
6.1
通讯作者：
K. Tournoy;J. Kips;C. Schou;R. Pauwels
中科院分区：
文献类型：
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作者：
K. Tournoy;J. Kips;C. Schou;R. Pauwels
屋尘螨是引起人类过敏性哮喘的主要常年性变应原。因此，尽可能模仿人类哮喘中观察到的过敏特征的动物模型是研究所涉及的免疫学和病理生理学机制的有趣工具。特别是嗜酸性粒细胞和过敏原特异性免疫球蛋白（IG）E在气道高反应性（AHR）病理生理学中的作用仍然是一个激烈争论的主题。
House dust mites (HDMs) are the major source of perennial allergens causing human allergic asthma. Animal models mimicking as closely as possible the allergic features observed in human asthma are therefore interesting tools for studying the immunological and pathophysiological mechanisms involved. Especially the role of eosinophils and allergen‐specific immunoglobulin (Ig) E in the pathophysiology of airway hyperresponsiveness (AHR) remains a subject of intense debate.