Adult Renal Cell Carcinoma: A Review of Established Entities from Morphology to Molecular Genetics.
Adult Renal Cell Carcinoma: A Review of Established Entities from Morphology to Molecular Genetics.
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DOI：
10.1016/j.path.2015.09.003
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发表时间：
2015-12-01
影响因子：
--
通讯作者：
Dal Cin, Paola
中科院分区：
文献类型：
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作者：
Hirsch, Michelle S;Signoretti, Sabina;Dal Cin, Paola
根据目前的世界卫生组织（WHO），主要影响成人的肾细胞癌（RCC）分为8个主要亚型。最近还认识到了肾脏肿瘤中的其他新实体，Mehra等人（Emerging Entities in Renal Neoplasia，Surgical Pathology Clinics，2015，Volume 8，Issue 4）对此进行了更详细的讨论。在大多数情况下，RCC亚型的诊断可以基于形态学标准，但在某些情况下，使用辅助研究可以帮助诊断。这篇综述讨论了以前由WHO认可的RCC的形态学、遗传学和分子学发现，并提供了区分彼此和一些较新的RCC亚型的线索。由于RCC的不同亚型的预后和治疗方案各不相同，因此准确的病理区分对患者护理至关重要。
According to the current World Health Organization (WHO), renal cell carcinomas (RCCs) that primarily affect adults are classified into 8 major subtypes. Additional emerging entities in renal neoplasia have also been recently recognized and these are discussed in further detail by Mehra et al (Emerging Entities in Renal Neoplasia, Surgical Pathology Clinics, 2015, Volume 8, Issue 4). In most cases, the diagnosis of a RCC subtype can be based on morphologic criteria, but in some circumstances the use of ancillary studies can aid in the diagnosis. This review discusses the morphologic, genetic, and molecular findings in RCCs previously recognized by the WHO, and provides clues to distinction from each other and some of the newer subtypes of RCC. As prognosis and therapeutic options vary for the different subtypes of RCC, accurate pathologic distinction is critical for patient care.