Intracellular signalling pathways and mood disorders.
Intracellular signalling pathways and mood disorders.
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作者：
Z. Fišar;J. Hroudová
研究结果总结了影响神经传递和参与神经退行性疾病或神经精神疾病的基本细胞内信号通路。精神药物用于治疗一系列精神障碍，特别是心境障碍，长期使用后表现出神经营养或神经保护作用。因此，除了腺苷酸环化酶、鸟苷酸环化酶和钙系统之外，酪氨酸激酶途径和Wnt途径也受到了关注。公开了情绪障碍的新的神经化学假说;它们是基于抗抑郁药或情绪稳定剂对细胞内信号转导，即对神经元的功能、可塑性和存活的已知作用而制定的。这些假说集中在细胞内信号通路的成分，可以作为情绪障碍的生物标志物进行研究：转录因子CREB，神经营养因子BDNF及其trkB受体，抗凋亡因子Bcl 2，促凋亡酶GSK 3，半胱天冬酶，钙，以及一些与脑能量代谢相关的线粒体功能。
Findings are summarized about basic intracellular signalling pathways influencing neurotransmission and involved in neurodegenerative or neuropsychiatric disorders. Psychotropic drugs used in the therapy of a series of mental disorders, mood disorders especially, show neurotrophic or neuroprotective effects after long-term treatment. Thus, beyond adenylate cyclase, guanylate cyclase and calcium system, attention has been paid to the tyrosine kinase pathway and Wnt pathway. New neurochemical hypotheses of mood disorders are disclosed; they were formulated on the basis of known effects of antidepressants or mood stabilizers on intracellular signal transduction, i.e. on the function, plasticity and survival of neurons. These hypotheses focus on the constituents of intracellular signalling pathways that could be studied as biological markers of mood disorders: transcription factor CREB, neurotrophin BDNF and its trkB receptor, anti-apoptotic factor Bcl2, pro-apoptotic enzyme GSK3, caspases, calcium, and a number of mitochondrial functions related to brain energy metabolism.