Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis.
Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis.
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DOI：
10.3389/fcell.2022.973548
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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背景资料：评估接受根治性部分肝切除术的B型肝炎病毒（HBV）阳性亚洲小肝癌（sHCC）患者肿瘤和配对相邻非肿瘤性肝组织（PANLT）中WTAP水平的预后价值。 方法：采用两个外部队列进行调查。用限制性三次样条模型研究了复发风险与连续WTAP水平之间的关系。建立考克斯模型和逆概率加权模型进行生存分析。基于交互作用效应，进行进一步分层分析。采用里程碑分析来分析晚期复发病例。最后，进行敏感性分析，以评估未测量的混杂因素。 调查结果：在307例患者的研究队列中，限制性三次样条模型表明复发的危险风险随着sHCC和PANLT的WTAP水平升高而增加。然而，使用考克斯和逆概率加权模型，在sHCC中具有不同WTAP水平的组之间没有观察到无复发生存期（RFS）的显著差异。多变量分析显示，PANLT WTAP水平高的患者RFS显著更差（HR 1.567，95% CI 1.065-2.307; p = 0.023）。基于sHCC和PANLT中WTAP水平之间的显著相互作用效应，分层分析显示PANLT和sHCC中WTAP水平高的患者复发风险更明显。标志性分析显示，晚期复发更可能发生在PANLT WTAP水平较高的患者中（HR 2.058，95% CI 1.113-3.805; p = 0.021）。此外，PANLT WTAP水平升高对RFS的不利影响用两个外部队列进行了验证。敏感性分析证实了结果的稳健性。 结论：PANLT WTAP表达水平升高独立预测HBV阳性亚洲sHCC患者的高复发风险。在未来的临床实践中，需要将肿瘤组织和PANLT一起考虑，以获得更全面和准确的复发风险评估。
Background: To evaluate prognostic value of WTAP levels in tumor and paired adjacent non-neoplastic liver tissues (PANLT) for cases of hepatitis B virus (HBV)-positive Asian small hepatocellular carcinoma (sHCC) patients who received curative partial hepatectomy. Method: The investigation with two external cohorts were included. Associations between hazard risk of recurrence and continuous WTAP levels were investigated with restricted cubic spline models. Cox and inverse probability weighting models were established for survival analysis. Based on interaction effects, further stratification analysis was performed. Landmark analysis was employed to analyze cases of late recurrence. Finally, sensitivity analysis was performed to assess unmeasured confounders. Findings: In an investigation cohort of 307 patients, restricted cubic spline models indicated that hazard risk of recurrence increases with elevated WTAP levels for sHCC and PANLT. However, using Cox and inverse probability weighting models, no significant differences were observed in recurrence-free survival (RFS) between groups with different WTAP levels in sHCC. Multivariate analysis showed that patients with high PANLT WTAP levels had significantly worse RFS (HR 1.567, 95% CI 1.065–2.307; p = 0.023). Based on the significant interaction effect between WTAP levels in sHCC and PANLT, stratification analysis revealed that recurrence risk is more pronounced in patients with high WTAP levels in both PANLT and sHCC. Landmark analysis showed that late recurrence was more likely to occur in patients with high PANLT WTAP levels (HR 2.058, 95% CI 1.113–3.805; p = 0.021). Moreover, the detrimental effects of elevated PANLT WTAP levels on RFS were validated with two external cohorts. Sensitivity analysis confirmed the robustness of results. Conclusion: Increased PANLT WTAP expression levels independently predict high recurrence risk in HBV-positive Asian sHCC patients. Both tumor tissues and PANLT need to be considered together in future clinical practice to obtain a more comprehensive and accurate evaluation for recurrence risk.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
81.5
作者：
Llovet, Josep M.;Zucman-Rossi, Jessica;Gores, Gregory
通讯作者：
Gores, Gregory
影响因子：
25.7
作者：
Fujiwara N;Friedman SL;Goossens N;Hoshida Y
通讯作者：
Hoshida Y
DOI：
10.1186/s13046-018-0706-6
发表时间：
2018-02-27
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Tang J;Wang F;Cheng G;Si S;Sun X;Han J;Yu H;Zhang W;Lv Q;Wei JF;Yang H
通讯作者：
Yang H
影响因子：
13.5
作者：
Kruse, Robert L.;Kramer, Jennifer R.;Tyson, Gia L.;Duan, Zhigang;Chen, Liang;El-Serag, Hashem B.;Kanwal, Fasiha
通讯作者：
Kanwal, Fasiha