HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria.
HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria.
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DOI：
10.3389/fmed.2021.718300
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发表时间：
2021
影响因子：
3.9
通讯作者：
Adu D
中科院分区：
文献类型：
--
作者：
Kruzel-Davila E;Sankofi BM;Kubi Amos-Abanyie E;Ghansah A;Nyarko A;Agyemang S;Awandare GA;Szwarcwort-Cohen M;Reiner-Benaim A;Hijazi B;Ulasi I;Raji YR;Boima V;Osafo C;May Adabayeri V;Matekole M;Olanrewaju TO;Ajayi S;Mamven M;Antwi S;Ademola AD;Plange-Rhule J;Arogundade F;Akyaw PA;Winkler CA;Salako BL;Ojo A;Skorecki K;Adu D
载脂蛋白L1(APOL1)基因变异(G1-rs60910145、rs73885319、G2-rs71785313)在非洲人和最近非洲血统的人中很常见，与非糖尿病慢性肾脏疾病(CKD)，特别是艾滋病毒相关肾病(HIVAN)的风险增加有关。鉴于两个APOL1风险等位基因携带者感染HIVAN的风险显著增加，推测在APOL1相关肾脏疾病的发病机制中，HIV的感染性起到了一定作用。在此，我们旨在探讨HIV病毒血症与APOL1基因之间的关系。此外，我们还研究了BK和JC病毒尿症、CKD和HIV病毒血症之间的相互作用。从正在进行的非洲人类遗传与健康(H3 Africa)肾脏疾病研究网络病例对照研究的参与者中招募了199名艾滋病毒/艾滋病患者(包括82例慢性肾脏病病例和117例对照)。两种载脂蛋白1肾病风险等位基因与慢性肾脏病的风险相关(OR12.6，95%CI3.89~40.8，p<；0.0001)。即使单个APOL1RRA与CKD风险相关(OR4.42，95%CI1.49-13.15，p=0.007)。2个APOL1 RRA基因型与HIV病毒血症的发生相关(OR2.37，95%CI 1.0~5.63，p=0.05)。HIV病毒血症与慢性肾脏病风险增加(OR7.45，95%CI1.66~33.35，P=0.009)和JC病毒尿漏显著减少(OR0.35，95%CI0.12~0.98，P=0.046)相关。与以前的研究相反，JC病毒尿与CKD无关，但仅限于HIV病毒血症患者，无论CKD状态如何。这些发现提示APOL1变异在HIV感染性中的作用，并强调JC病毒尿可以作为天然免疫系统激活的生物标记物。
Variants in the Apolipoprotein L1 (APOL1) gene (G1-rs60910145, rs73885319, G2-rs71785313) are common in Africans and in individuals of recent African ancestry and are associated with an increased risk of non-diabetic chronic kidney disease (CKD) and in particular of HIV associated nephropathy (HIVAN). In light of the significantly increased risk of HIVAN in carriers of two APOL1 risk alleles, a role in HIV infectivity has been postulated in the mechanism of APOL1 associated kidney disease. Herein, we aim to explore the association between HIV viremia and APOL1 genotype. In addition, we investigated interaction between BK and JC viruria, CKD and HIV viremia. A total of 199 persons living with HIV/AIDS (comprising 82 CKD cases and 117 controls) from among the participants in the ongoing Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network case control study have been recruited. The two APOL1 renal risk alleles (RRA) genotypes were associated with a higher risk of CKD (OR 12.6, 95% CI 3.89–40.8, p < 0.0001). Even a single APOL1 RRA was associated with CKD risk (OR 4.42, 95% CI 1.49–13.15, p = 0.007). The 2 APOL1 RRA genotypes were associated with an increased probability of having HIV viremia (OR 2.37 95% CI 1.0–5.63, p = 0.05). HIV viremia was associated with increased CKD risk (OR 7.45, 95% CI 1.66–33.35, P = 0.009) and with a significant reduction of JC virus urine shedding (OR 0.35, 95% CI 0.12–0.98, p = 0.046). In contrast to prior studies, JC viruria was not associated with CKD but was restricted in patients with HIV viremia, regardless of CKD status. These findings suggest a role of APOL1 variants in HIV infectivity and emphasize that JC viruria can serve as biomarker for innate immune system activation.
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DOI：
10.1126/science.1193032
发表时间：
2010-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Genovese G;Friedman DJ;Ross MD;Lecordier L;Uzureau P;Freedman BI;Bowden DW;Langefeld CD;Oleksyk TK;Uscinski Knob AL;Bernhardy AJ;Hicks PJ;Nelson GW;Vanhollebeke B;Winkler CA;Kopp JB;Pays E;Pollak MR
通讯作者：
Pollak MR
影响因子：
120.7
作者：
Gunthard, Huldrych F.;Saag, Michael S.;Benson, Constance A.;del Rio, Carlos;Eron, Joseph J.;Gallant, Joel E.;Hoy, Jennifer F.;Mugavero, Michael J.;Sax, Paul E.;Thompson, Melanie A.;Gandhi, Rajesh T.;Landovitz, Raphael J.;Smith, Davey M.;Jacobsen, Donna M.;Volberding, Paul A.
通讯作者：
Volberding, Paul A.
影响因子：
6.5
作者：
Brauweiler, Anne M.;Goleva, Elena;Leung, Donald Y. M.
通讯作者：
Leung, Donald Y. M.
影响因子：
11.8
作者：
Estrella, Michelle M.;Li, Man;Kao, W. H. Linda
通讯作者：
Kao, W. H. Linda
影响因子：
13.6
作者：
Kopp, Jeffrey B.;Nelson, George W.;Winkler, Cheryl A.
通讯作者：
Winkler, Cheryl A.