Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation.
Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation.
复制标题
DOI：
10.1161/circresaha.120.316857
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ding Ai
中科院分区：
文献类型：
--
作者：
Chenghu Zhang;Ting Zhou;Zhipeng Chen;Meng Yan;Bochuan Li;Huizhen Lv;Chunjiong Wang;Song Xiang;Lei Shi;Yi Zhu;Ding Ai
Atherosclerosis preferentially occurs at specific sites of the vasculature where endothelial cells(ECs) are exposed to disturbed blood flow. Translocation of integrin α5 to lipid rafts promotes integrin activation and ligation, which is critical for oscillatory shear stress (OSS)-induced EC activation. However, the underlying mechanism of OSS promoted integrin α5 lipid raft translocation has remained largely unknown.
