RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo
RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo
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DOI：
10.1016/j.tetlet.2008.09.074
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发表时间：
2008-11-24
影响因子：
1.8
通讯作者：
Mori, Kenji
中科院分区：
文献类型：
--
作者：
Tashiro, Takuya;Nakagawa, Ryusuke;Mori, Kenji
合成了RCAI-61、KRN 7000的6 ′-O-甲基化类似物和其他六种KRN 7000半乳糖部分6 ′-位修饰的类似物，以检查它们对小鼠淋巴细胞的生物活性。甲基α-D-吡喃半乳糖苷是RCAI-58、61、64、83、85和86的起始物料，而RCAI-87是由甲基β-L-吡喃阿拉伯糖苷制备的。生物测定表明RCAI-61是一种比KRN 7000和RCAI-56更强的小鼠淋巴细胞刺激剂，在体内诱导大量IFN-γ的产生。(C)2008爱思唯尔有限公司保留所有权利。
RCAI-61, the 6'-O-methylated analog of KRN7000, and six other analogs with modified 6'-position of the galactose moiety of KRN7000 were synthesized to examine their bioactivity for mouse lymphocytes. Methyl alpha-D-galactopyranoside was the starting material for RCAI-58, 61, 64, 83, 85, and 86, while RCAI-87 was prepared from methyl beta-L-arabinopyranoside. Bioassay showed RCAI-61 to be a Much more potent stimulant of mouse lymphocytes than KRN7000 and RCAI-56 to induce the production of a large amount of IFN-gamma in vivo. (C) 2008 Elsevier Ltd. All rights reserved.