Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease.
Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease.
复制标题
在早期发现阿尔茨海默氏病时，磁共振成像可改善脑脊液生物标志物。
DOI：
10.3233/jad-2009-0968
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
de Leon MJ
中科院分区：
文献类型：
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作者：
Brys M;Glodzik L;Mosconi L;Switalski R;De Santi S;Pirraglia E;Rich K;Kim BC;Mehta P;Zinkowski R;Pratico D;Wallin A;Zetterberg H;Tsui WH;Rusinek H;Blennow K;de Leon MJ
磁共振成像（MRI）和脑脊液（CSF）生物标志物联合应用预测阿尔茨海默病（AD）的研究知之甚少，纵向数据也很少。我们检查了这些生物标志物在基线和纵向在早期AD。45例受试者[21例对照（NL-NL），16例稳定型MCI（MCI-MCI），8例下降至AD的MCI（MCI-AD）]在基线和2年后接受了MRI和腰椎穿刺。CSF测量包括总tau和磷酸化tau（T-tau、P-tau 231）、淀粉样蛋白-β（Aβ42/Aβ40）和异前列腺素。基于体素的形态测量确定了最佳区分研究组和个体GMC值的灰质浓度（GMC）差异。采用区域边界移位（rBS）法检测内侧颞叶（MTL）萎缩率。基线时，与MCI-MCI或NL-NL相比，MCI-AD的MRI显示GMC-MTL降低，CSF的T-tau、P-tau 231、IP升高，Aβ42/Aβ40降低。纵向上，MCI-AD组rBS-MTL萎缩高于MCI-MCI组或NL-NL组，尤其是左半球。CSF数据显示，与NL-NL相比，MCI-AD中异前列烷的纵向增加更大。组合基线CSF-P-tau 231和GMC-MTL显著地将总体预测从74%增加到84%（pstep <0.05）。这些结果提供了支持，包括多种形式的生物标志物在识别记忆诊所患者痴呆症的风险增加。
Little is known of combined utility of magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers for prediction of Alzheimer’s disease (AD) and longitudinal data is scarce. We examined these biomarkers at baseline and longitudinally in incipient AD. Forty-five subjects [21 controls (NL-NL), 16 stable MCI (MCI-MCI), 8 MCI who declined to AD (MCI-AD)] received MRI and lumbar puncture at baseline and after 2 years. CSF measures included total and phosphorylated tau (T-tau, P-tau231), amyloid-β (Aβ42/Aβ40) and isoprostane. Voxel-based morphometry identified gray matter concentration (GMC) differences best distinguishing study groups and individual GMC values were calculated. Rate of medial temporal lobe (MTL) atrophy was examined using regional boundary shift (rBS) method. At baseline, for MRI, MCI-AD showed reduced GMC-MTL, and for CSF higher CSF T-tau, P-tau231, IP and lower Aβ42/Aβ40 as compared with MCI-MCI or NL-NL. Longitudinally, rBS-MTL atrophy was higher in MCI-AD than in either MCI-MCI or NL-NL, particularly in the left hemisphere. CSF data showed longitudinally greater increases of isoprostane in MCI-AD as compared with NL-NL. Combining baseline CSF-P-tau231 and GMC-MTL significantly increased overall prediction from 74% to 84% (pstep <0.05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia.