Comparison of the effects of desmethylimipramine on behavior in the forced swim test in peripubertal and adult rats.
Comparison of the effects of desmethylimipramine on behavior in the forced swim test in peripubertal and adult rats.
复制标题
比较去甲基丙咪嗪对青春期前后和成年大鼠强迫游泳试验中行为的影响。
DOI：
10.1097/fbp.0b013e3282f3d07f
复制
发表时间：
2008
影响因子：
1.6
通讯作者：
Poland,RussellE
中科院分区：
文献类型：
--
作者：
Pechnick,RobertN;Bresee,CatherineJ;Manalo,CharleneM;Poland,RussellE
虽然青少年和成人抑郁症的临床表现有相似之处，但在生物学相关性和对药物治疗的反应方面存在差异。选择性5-羟色胺再摄取通道型抗抑郁药是有效的，但三环类抗抑郁药在治疗青少年患者时没有或疗效有限。强迫游泳试验（FST）是一种被广泛接受的动物模型，用于筛选抗抑郁活性的药物。目前尚不清楚三环类抗抑郁药是否在青春期和成年大鼠中产生不同的作用，就像在青少年和成年人中发现的那样。本研究的目的是检验以下假设：三环类抗抑郁药去甲基丙咪嗪（DEMETHYIMIPRAMINE，DEMETHYIMIPRAMINE）对成年大鼠FST有效，但对青春期大鼠无效。30日龄（青春期）和112日龄（年轻成年）大鼠用生理盐水或盐水预处理，并进行FST。在青春期前后和成年大鼠中，地塞米松减少了漂浮行为的数量，增加了攀爬行为的数量。因此，三环类抗抑郁药在FST中的青春期大鼠中具有抗抑郁样活性。由于临床前和临床数据之间的差异，FST的预测有效性可能需要重新评估不同年龄组。
Although there are similarities in the clinical presentation of adolescent and adult depression, there are differences in the biological correlates and the responses to pharmacologic treatment. Selective serotonin reuptake inhibitor-type antidepressants are efficacious, but tricyclic antidepressants have no or limited efficacy in treating adolescent patients. The forced swim test (FST) is a widely accepted animal model used to screen drugs for antidepressant activity. It is not known whether tricyclic antidepressants produce differential effects in peripubertal and adult rats, as is found in adolescent and adult humans. The objective of the study was to test the hypothesis that the tricyclic antidepressant desmethylimipramine (DMI) would show efficacy in the FST in adult, but not in peripubertal, rats. Thirty-day-old (peripubertal) and 112-day-old (young adult) rats were pretreated with saline or DMI and subjected to the FST. DMI reduced the amount of floating behavior and increased the amount of climbing behavior in both peripubertal and adult rats. Thus, the tricyclic antidepressant DMI has antidepressant-like activity in peripubertal rats in the FST. Owing to the discrepancy between the preclinical and clinical data, the predictive validity of the FST might need to be reevaluated across different age groups.