Tissue effects of saw palmetto and finasteride: Use of biopsy cores for in situ quantification of prostatic androgens
Tissue effects of saw palmetto and finasteride: Use of biopsy cores for in situ quantification of prostatic androgens
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DOI：
10.1016/s0090-4295(00)01052-9
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发表时间：
2001-05-01
期刊：
影响因子：
2.1
通讯作者：
Tyler, VE
中科院分区：
文献类型：
--
作者：
Marks, LS;Hess, DL;Tyler, VE
目标。确定锯棕榈草药混合物 (SPHB) 与非那雄胺相比对前列腺组织雄激素水平的影响，并评估针吸活检作为此类确定的组织来源。方法。在三组患有良性前列腺增生症状的男性中，通过 5 至 10 毫克活检标本（18 号针芯）测量前列腺的睾酮和二氢睾酮 (DHT) 水平：15 名接受长期非那雄胺治疗的男性与 7 名未经治疗的对照组； 4 名男性接受前列腺腺瘤切除术以确定采样变异性（每人 10 个样本）；以及 40 名男性参加了一项为期 6 个月的 SPHB 与安慰剂治疗前后随机试验。结果。研究发现，前列腺组织中的 DHT 水平比睾酮水平高出数倍（5.01 ng/g 与 1.51 ng/g），而长期非那雄胺治疗后，这一比例发生逆转（1.05 ng/g 与 3.63 ng/g）。非那雄胺对两种雄激素的影响均具有统计学显着性（P
Objectives. To determine the effects of a saw palmetto herbal blend (SPHB) compared with finasteride on prostatic tissue androgen levels and to evaluate needle biopsies as a source of tissue for such determinations.Methods. Prostate levels of testosterone and dihydrotestosterone (DHT) were measured on 5 to 10-mg biopsy specimens (18-gauge needle cores) in three groups of men with symptomatic benign prostatic hyperplasia: 15 men receiving chronic finasteride therapy versus 7 untreated controls; 4 men undergoing prostate adenomectomy to determine sampling variability (10 specimens each); and 40 men participating in a 6-month randomized trial of SPHB versus placebo, before and after treatment.Results. Prostatic tissue DHT levels were found to be several times higher than the levels of testosterone (5.01 versus 1.51 ng/g), that ratio becoming reversed (1.05 versus 3.63 ng/g) with chronic finasteride therapy. The finasteride effect was statistically significant for both androgens (P