Amidoxime-Functionalized Covalent Organic Nanosheets for Sequestration of Uranium In Vivo
Amidoxime-Functionalized Covalent Organic Nanosheets for Sequestration of Uranium In Vivo
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用于体内铀封存的偕胺肟功能化共价有机纳米片
DOI：
10.1021/acsabm.0c01122
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发表时间：
2020
影响因子：
4.7
通讯作者：
Diwu Juan
中科院分区：
文献类型：
--
作者：
Chen Long;Bai Ru;Wang Xiaomei;Zhang Yijing;He Linwei;Zhang Mingxing;Chong Yu;Chai Zhifang;Wang Xiao-Feng;Diwu Juan
寻找有效的锕系元素脱硝剂对公众健康和核工业的发展至关重要。目前的去杂剂主要限于少数配体。在这项工作中，一个二维（2D）共价有机纳米片（CON）材料的合理设计和测试，在体内的铀去离子。这种材料广泛接枝有偕胺肟（AO），一种经典的铀识别配体，它不仅为铀酰提供选择性结合位点，而且还扩大了CON的层间距，使活性位点更容易接近。值得注意的是，体内实验的结果表明，在预防性和即时给药组中，CON-AO显示出比ZnNa 3-二亚乙基三胺五乙酸盐（DTPA）更高的肾铀排泄率，同时显示出相似的细胞毒性水平。这些结果表明，功能化的CON可能会成为一个有前途的类型的锕系元素在体内decomposition剂。
Finding efficient actinide decorporation agents is crucial for public health and the development of the nuclear industry. The current inventory of decorporation agents is predominately limited to a handful of ligands. In this work, a two-dimensional (2D) covalent organic nanosheet (CON) material was rationally designed and tested for in vivo uranium decorporation. This material is extensively grafted with amidoxime (AO), a classic uranium-recognition ligand, which not only provides selective binding sites for uranyl but also expands the interlayer spacing of CON, making the active sites more accessible. Significantly, the results of in vivo experiments demonstrate that, in both prophylactic and prompt administration groups, CON-AO exhibits a higher excretion ratio of uranium from kidneys than that of ZnNa3-diethylenetriamine pentaacetate (DTPA), while presenting a similar level of cytotoxicity. These results suggest that functionalized CONs may emerge as a promising type of actinide in vivo decorporation agent.