ATHEROSCLEROSIS OF THE AORTA AND CORONARY-ARTERIES AND CARDIOVASCULAR RISK-FACTORS IN PERSONS AGED 6 TO 30 YEARS AND STUDIED AT NECROPSY (THE BOGALUSA HEART-STUDY)
ATHEROSCLEROSIS OF THE AORTA AND CORONARY-ARTERIES AND CARDIOVASCULAR RISK-FACTORS IN PERSONS AGED 6 TO 30 YEARS AND STUDIED AT NECROPSY (THE BOGALUSA HEART-STUDY)
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DOI：
10.1016/0002-9149(92)90726-f
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发表时间：
1992-10-01
影响因子：
2.8
通讯作者：
STRONG, JP
中科院分区：
文献类型：
--
作者：
BERENSON, GS;WATTIGNEY, WA;STRONG, JP
本文研究了150例6 ~ 30岁男性的主动脉和冠状动脉粥样硬化病变的种族和性别差异。动脉脂肪条纹累及内膜表面的范围很广（0 ~ 71%），黑人比白人更大（32%比20%，p < 0.001）。男性冠状动脉脂肪条纹比女性更广泛（范围0 - 22%）。纤维斑块病变存在，但在主动脉（0 - 12%）或冠状动脉（0 - 24%）标本中不广泛。病变在男性中比在女性中更普遍，尤其是白人男性受试者。脂肪条纹与纤维斑块的关系在冠状血管中比在主动脉中更明显。在男性受试者中，主动脉脂肪条纹与白人男性死前总胆固醇、低密度脂蛋白胆固醇和ponderal指数水平密切相关。白人男性冠状动脉脂肪条纹与血清甘油三酯、极低密度脂蛋白胆固醇、收缩压和舒张压和ponderal指数显著相关。这些结果将死前危险因素与动脉粥样硬化病变的发展联系起来，并强调在生命早期预防心脏病学的必要性。
Race and sex differences in aorta and coronary atherosclerotic lesions were studied in 150 persons sons aged 6 to 30 years. The intimal surface involvement with aorta fatty streaks was extensive, 0 to 71%, and greater in blacks than in whites (32 vs 20%, p < 0.001). Coronary artery fatty streaks were more extensive in male than in female subjects (range 0 to 22%). Fibrous plaque lesions were present but not extensive in either the aorta (0 to 12%) or the coronary artery (0 to 24%) specimens. Lesions were more prevalent in male than in female persons, particularly white male subjects. The relation of fatty streaks to fibrous plaques was greater in the coronary vessels than in the aorta. In male subjects, aorta fatty streaks were strongly related to antemortem levels of total cholesterol, low-density lipoprotein cholesterol and ponderal index in white male subjects Coronary artery fatty streaks in white male persons were significantly associated with serum triglycerides, very low density lipoprotein cholesterol, systolic and diastolic blood pressure and ponderal index. These results link antemortem risk factors to the development of atherosclerotic lesions and emphasize the need for preventive cardiology in early life.