Nerve growth factor modulation of the cavernous nerve response to injury.
Nerve growth factor modulation of the cavernous nerve response to injury.
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DOI：
10.1111/j.1743-6109.2008.01194.x
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Lue TF
中科院分区：
文献类型：
--
作者：
Bella AJ;Lin G;Lin CS;Hickling DR;Morash C;Lue TF
前列腺癌和其他盆腔恶性肿瘤的手术治疗通常会因海绵神经损伤而导致神经元损伤和性功能丧失。生长因子神经生物学的进展提高了临床对开发针对损伤后海绵体神经恢复的保护性和再生性神经调节策略的兴趣。本综述的目的是对当前和未来的神经生长因子对海绵体神经损伤反应的调节进行检查，重点关注脑源性神经生长因子、生长分化因子 5 和神经营养因子。本演示文稿的信息源自使用国家医学图书馆 PubMed 服务制作的与该主题相关的出版物的当前文献检索。搜索词包括神经保护、神经再生、神经生长因子、神经营养因子、脑源性神经生长因子 (BDNF)、生长分化因子 5 (GDF-5)、神经营养因子 (NTN) 和海绵神经。对满足检索纳入标准的基础科学研究进行了审查。在本次会议中，回顾了 BDNF 和非典型生长因子 GDF-5 和 NTN，以及它们对损伤后海绵神经恢复的潜在影响，以及它们发挥影响的分子途径。海绵体神经功能受损是前列腺切除术后勃起功能障碍的一个重要原因，并且是利用 BDNF、GDF-5 和 NTN 等神经生长因子和/或调节信号通路的靶向新型疗法的潜在神经保护或再生策略的主要目标。
Surgical therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function due to cavernous nerve trauma. Advances in the neurobiology of growth factors have heightened clinical interest for the development of protective and regenerative neuromodulatory strategies targeting cavernous nerve recovery following injury. The aim of this review is to offer an examination of current and future nerve growth factor modulation of cavernous nerve response to injury with a focus on brain-derived nerve growth factor, growth-differentiation factor 5, and neurturin. Information for this presentation was derived from a current literature search using the National Library of Medicine PubMed Services producing publications relevant to this topic. Search terms included neuroprotection, nerve regeneration, nerve growth factors, neurotrophic factors, brain-derived nerve growth factor (BDNF), growth-differentiation factor 5 (GDF-5), neurturin (NTN), and cavernous nerves. Basic science studies satisfying the search inclusion criteria were reviewed. In this session, BDNF and atypical growth factors GDF-5 and NTN, and their potential influence upon cavernous nerve recovery after injury is reviewed, as are the molecular pathways by which their influence is exerted. Compromised cavernous nerve function is a significant cause of erectile dysfunction development following prostatectomy and serves as the primary target for potential neuroprotective or regenerative strategies utilizing nerve growth factors such as BDNF, GDF-5, and NTN, and/or targeted novel therapeutics modulating signaling pathways.
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DOI：
10.1186/1749-7221-2-5
发表时间：
2007-12-01
影响因子：
0.7
作者：
Bella, Anthony J.;Fandel, Thomas M.;Lue, Tom F.
通讯作者：
Lue, Tom F.
影响因子：
3.5
作者：
Lin, Guiting;Bella, Anthony J.;Lin, Ching-Shwun
通讯作者：
Lin, Ching-Shwun
影响因子：
23.4
作者：
Bella, Anthony J.;Lin, Guiting;Lue, Tom F.
通讯作者：
Lue, Tom F.
影响因子：
6.6
作者：
Kessler, TM;Burkhard, FC;Studer, UE
通讯作者：
Studer, UE
影响因子：
4.5
作者：
Hsieh, PS;Bochinski, DJ;Lue, TF
通讯作者：
Lue, TF