Regulation of hexitol catabolism in Streptococcus mutans
Regulation of hexitol catabolism in Streptococcus mutans
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变形链球菌己糖分解代谢的调节
DOI：
10.1128/jb.153.2.861-866.1983
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发表时间：
1983
影响因子：
3.2
通讯作者：
S. Senot
中科院分区：
文献类型：
--
作者：
S. Dills;S. Senot
己糖醇催化剂的调节在变形链球菌中进行了研究，变形链球菌是一种致龋的人类牙菌斑细菌。诱导己糖醇分解代谢酶和磷酸烯醇丙酮酸：己糖醇磷酸转移酶和磷酸己糖醇脱氢酶活性调节诱导剂排斥机制启动的D-葡萄糖和2-脱氧-D-葡萄糖。2-脱氧-D-葡萄糖对初始己糖醇摄入的抑制作用的动力学分析表明，这是一种非竞争性抑制类型。在S.缺乏磷酸烯醇式丙酮酸：葡萄糖磷酸转移酶活性的变形杆菌，2-脱氧-D-葡萄糖不能抑制己糖醇摄取。这些观察结果为排除过程的可能分子机制提供了证据。
Regulation of hexitol catabolism was investigated in Streptococcus mutans, a cariogenic human dental plaque bacterium. Induction of hexitol catabolic enzymes and phosphoenolpyruvate:hexitol phosphotransferase and hexitol phosphate dehydrogenase activities was regulated by an inducer exclusion mechanism initiated by D-glucose and 2-deoxy-D-glucose. Kinetic analysis of the inhibitory effect of 2-deoxy-D-glucose on initial hexitol uptake illustrated that this was a noncompetitive type of inhibition. In mutant strains of S. mutans lacking phosphoenolpyruvate:glucose phosphotransferase activity, 2-deoxy-D-glucose was unable to inhibit hexitol uptake. These observations provide evidence for possible molecular mechanisms for the exclusion process.
通过排出机制调节化脓性链球菌中β-半乳糖苷磷酸盐的积累。
DOI：
10.1073/pnas.77.9.5497
发表时间：
1980
影响因子：
11.1
作者：
Reizer,J;Panos,C
通讯作者：
Panos,C