The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment
The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment
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DOI：
10.1007/s12032-009-9335-4
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发表时间：
2010-12-01
期刊：
影响因子：
3.4
通讯作者：
Gumus, Mahmut
中科院分区：
文献类型：
--
作者：
Aliustaoglu, Mehmet;Bilici, Ahmet;Gumus, Mahmut
目的探讨中性粒细胞、淋巴细胞、血小板、血小板平均值（MPV）、血小板-淋巴细胞比率（PLR）、嗜中性粒细胞-淋巴细胞比率（NLR）在局部进展期胃癌（LAGC）患者中的预后意义。本研究纳入了2004年至2008年随访的168例LAGC患者。治疗前检测血液学指标（血小板、淋巴细胞、中性粒细胞、MPV）和生化指标（尿酸、乳酸脱氢酶）。NLR分为两组，共< 2.56 and a parts per thousand yen2.57 and PLR was also divided into two groups as a parts per thousand currency sign160 and >160例。血小板计数和淋巴细胞计数也被分为两组;分别为千分之300.000/mm 3和> 300.000/mm 3，以及<1，500/mm 3和千分之1，500/mm 3。采用Kaplan-Meier和Long-rank检验对结果进行评价。诊断时患者的平均年龄为60.1 ± 12.1岁，114例患者（67.8%）为男性。168例患者的48个月总生存率（OS）为45.2%，中位OS为39个月（范围33-44）。在PLR小于160的患者中（n = 54），中位OS为45个月（范围38-52），PRL大于160的患者中（n = 114），中位OS为27个月（范围22-32）（p = 0.006）。而对于淋巴细胞计数小于1，500的50例患者，中位OS为27个月（范围21-33），在淋巴细胞计数高的病例中（每千日元1，500分之一）（n = 118），为41个月（范围35-48）（p = 0.03）。两个血小板组的中位OS分别为41（范围34-48）和30（范围23-37）个月（p = 0.24）。然而，在NLR小于2.56的患者中（n = 107），中位OS优于NLR大于或等于2.56的患者（42 vs 27个月）。外周血常规计数可作为判断胃癌根治术后危险分层准确性的有效预后指标。
We aimed to investigate the prognostic significance of neutrophil, lymphocyte, platelet, mean platelet value (MPV), platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) in patients with locally advanced gastric cancer (LAGC). One hundred sixty-eight patients with LAGC who had been followed-up between 2004 and 2008 were included in present study. The results of hematological (platelet, lymphocyte, neutrophil and MPV) and biochemical (uric acid and LDH) parameters were evaluated before treatment. NLR was divided into two groups as < 2.56 and a parts per thousand yen2.57 and PLR was also divided into two groups as a parts per thousand currency sign160 and > 160. Platelet counts and lymphocyte counts were also divided into two groups; a parts per thousand currency sign300.000/mm3 and > 300.000/mm3, and < 1,500/mm3 and a parts per thousand yen1,500/mm3, respectively. Results were evaluated with Kaplan-Meier and Long-rank tests. The mean age of patients at diagnosis was 60.1 +/- A 12.1 and 114 of patients (67.8%) were male. For 168 patients, 48 months overall survival (OS) rate was 45.2% and the median OS was 39 months (range 33-44). In patients whose PLR was less than 160 (n = 54), the median OS was 45 months (range 38-52) and also for cases whose PRL was greater than 160 (n = 114), the median OS was 27 months (range 22-32) (p = 0.006). While for fifty patients whose lymphocyte counts were less than 1,500, the median OS was 27 months (range 21-33), in cases with high lymphocyte counts (a parts per thousand yen1,500) (n = 118), it was 41 months (range 35-48) (p = 0.03). The median OS was 41 (range 34-48) and 30 (range 23-37) months in two platelets groups, respectively (p = 0.24). However, in the patients whose NLR was less than 2.56 (n = 107), median OS was better than with cases whose NLR was greater than or equal to 2.56 (42 vs. 27 months). Routine peripheral blood counts may be useful prognostic factor for evaluating the accuracy of risk stratification in patients with radically resected gastric cancer Our results need to be confirmed by study including larger sample size in future.