Changes of Circulating Transforming Growth Factor-β1 Level During Radiation Therapy Are Correlated with the Prognosis of Locally Advanced Non-small Cell Lung Cancer
Changes of Circulating Transforming Growth Factor-β1 Level During Radiation Therapy Are Correlated with the Prognosis of Locally Advanced Non-small Cell Lung Cancer
复制标题
DOI：
10.1097/jto.0b013e3181cbf761
复制
发表时间：
2010-04-01
影响因子：
20.4
通讯作者：
Wang, Luhua
中科院分区：
文献类型：
--
作者：
Zhao, Lujun;Ji, Wei;Wang, Luhua
前言：我们假设局部晚期非小细胞肺癌放疗患者的血浆转化生长因子-β1水平及其动态变化与其预后有关。于放疗前1周内(放疗前)和放疗中4周(放疗中)采集血小板贫乏血浆。采用酶联免疫吸附试验检测血清转化生长因子-β1水平。主要终点为总生存期(OS)，次要终点为无进展生存期(PFS)。采用Kaplan-Meier和Cox回归进行危险因素评估。结果：65例患者符合研究条件。中位OS为17.7个月，PFS为13.7个月。在单因素分析中，运动状态、体重减轻、放射剂量和转化生长因子-β1比率(放疗中/放疗前的转化生长因子-β1水平)均与OS显著相关。在多变量分析中，表现状态、辐射剂量和转化生长因子-β1比率仍与OS显著相关。转化生长因子-β1比值患者的中位OS为30.7个月
Introduction: We hypothesized that plasma transforming growth factor-beta 1 (TGF-beta 1) level and its dynamic change are correlated with the prognosis of locally advanced non-small cell lung cancer (NSCLC) treated with radiation therapy (RT).Methods: Patients with stage IIIA or IIIB NSCLC treated with RT with or without chemotherapy were eligible for this study. Platelet poor plasma was collected from each patient within 1 week before RT (pre-RT) and at the 4th week during RT (during-RT). TGF-beta 1 level was measured with enzyme-linked immunosorbent assay. The primary end point was overall survival (OS) and the secondary end point was progression-free survival (PFS). Kaplan-Meier and Cox regression were used for risk factor evaluation.Results: A total of 65 patients were eligible for the study. The median OS and PFS were 17.7 and 13.7 months, respectively. In univariate analysis, performance status, weight loss, radiation dose, and TGF-beta 1 ratio (during-RT/pre-RT TGF-beta 1 level) were all significantly correlated with OS. In the multivariate analysis, performance status, radiation dose, and TGF-beta 1 ratio were still significantly correlated with OS. The median OS was 30.7 months for patients with TGF-beta 1 ratio