Functional DNAzymes organized into two-dimensional arrays
Functional DNAzymes organized into two-dimensional arrays
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DOI：
10.1021/nl0609955
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发表时间：
2006-07-12
期刊：
影响因子：
10.8
通讯作者：
Seeman, Nadrian C.
中科院分区：
文献类型：
--
作者：
Garibotti, Alejandra V.;Knudsen, Scott M.;Seeman, Nadrian C.
DNA酶是具有催化活性的DNA分子，其先前已在溶液中描述。在这里，我们将这些分子组织成一系列的二维（2D）阵列，使用基于DNA双交叉基序的DNA结构的周期性排列。我们证明了通过原子力显微镜的DNA酶的组织根据设计，它们保留其活性时，附加在线性字符串的上下文中的二维阵列。
DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array.