Circadian System and Glucose Metabolism: Implications for Physiology and Disease.
Circadian System and Glucose Metabolism: Implications for Physiology and Disease.
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DOI：
10.1016/j.tem.2016.03.005
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Scheer FAJL
中科院分区：
文献类型：
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作者：
Qian J;Scheer FAJL
昼夜节律系统是几乎所有生物体中最基本的特性之一：它在行为和生理过程中产生24小时节律，并能够预测和适应日常环境变化。最近的研究表明，昼夜节律系统在调节葡萄糖代谢的日节律中是重要的。这种昼夜节律控制或其相对于环境/行为周期的协调的紊乱，例如轮班工作，进食晚或由于遗传变化，导致血糖控制紊乱和2型糖尿病风险增加。因此，深入了解昼夜节律系统及其干扰的葡萄糖调节机制可能有助于开发针对昼夜节律紊乱的有害健康后果的治疗干预措施。
The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-hr rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Recent studies indicate that the circadian system is important in regulating the daily rhythm in glucose metabolism. Disturbance of this circadian control or of its coordination relative to the environmental/behavioral cycle, such as in shift work, eating late or due to genetic changes, results in disturbed glucose control and increased type 2 diabetes risk. Therefore, an in-depth understanding of the mechanisms underlying glucose regulation by the circadian system and its disturbance may help in the development of therapeutic interventions against the deleterious health consequences of circadian disruption.