New drugs for Alzheimer's disease and other dementias
New drugs for Alzheimer's disease and other dementias
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DOI：
10.1192/bjp.180.2.135
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发表时间：
2002-02-01
影响因子：
10.5
通讯作者：
Bullock, R
中科院分区：
文献类型：
--
作者：
Bullock, R
背景
阿尔茨海默病的治疗涉及英国国家卫生与临床优化研究所批准的对症药物治疗。如今，疾病修饰是治疗目标。
目的
综述阿尔茨海默病的现有及研发中的药物、其使用方法以及已知事实的临床背景，并提出具体模型。
方法
进行了一次简要的循证综述，利用现有文献，若文献缺失则采用共识小组的证据。
结果
有充分证据支持使用胆碱酯酶抑制剂，或许还有维生素E。雌激素和抗炎药有一定可能性，但没有足够证据支持常规使用。
结论
阿尔茨海默病存在对症治疗方法。观察性研究以及对脑生物学认识的不断增加正促使产生更多的治疗选择。老年精神病学家拥有有价值的治疗方法，他们现在必须学会使用。
利益声明
R.B.曾参与所有主要制药公司的痴呆症临床试验。
Background Alzheimer's disease management involves symptomatic drug treatments passed by the National Institute for Clinical Excellence. Disease modification is now the goal.Aims To review current and developmental drugs for Alzheimer's disease, their usage, and the clinical context of known facts and proposed specific models.Method A brief evidence- based review was made, using literature where available, or evidence from consensus groups where it was absent.Results There is good evidence to support the use of cholinesterase inhibitors, and perhaps vitamin E. Oestrogen and anti -inflammatory agents show possibility, but there is not enough evidence to support routine use.Conclusions Symptomatic treatments exist for Alzheimer's disease. Observational studies and increasing knowledge of brain biology are leading towards further treatment options. Old age psychiatrists have valuable treatments they now have to learn to use.Declaration of interest R.B. has worked on clinical trials in dementia for all the major pharmaceutical companies.