A retrospective study of the relation between vaccination and occurrence of seizures in Dravet syndrome
A retrospective study of the relation between vaccination and occurrence of seizures in Dravet syndrome
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DOI：
10.1111/j.1528-1167.2010.02885.x
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发表时间：
2011-01-01
期刊：
影响因子：
5.6
通讯作者：
Kluger, Gerhard
中科院分区：
文献类型：
--
作者：
Tro-Baumann, Blanca;von Spiczak, Sarah;Kluger, Gerhard
Dravet综合征是一种严重的癫痫性脑病，开始于生命的第一年。在大多数患者中可以识别出SCN1A的突变，并且在发烧的情况下癫痫发作是临床标志。接种疫苗后发热也很常见，Dravet综合征患者接种疫苗可诱发癫痫发作已有报道，但未进行系统评估。在对70例Dravet综合征和SCN 1A突变患者的回顾性评价中，27%的患者报告了疫苗接种后的癫痫发作。在这些患者中，58%的疫苗接种相关癫痫发作是首次临床表现。大多数癫痫发作发生在DPT疫苗接种后和接种后72小时内。三分之二的事件发生在发热的背景下。我们的研究结果强调了疫苗接种后癫痫发作是Dravet综合征的一个共同特征，并强调了对这些儿童因疫苗接种或发热引发的癫痫发作采取预防措施的必要性。
P>Dravet syndrome is a severe epileptic encephalopathy starting in the first year of life. Mutations in SCN1A can be identified in the majority of patients, and epileptic seizures in the setting of fever are a clinical hallmark. Fever is also commonly seen after vaccinations and provocation of epileptic seizures by vaccinations in patients with Dravet syndrome has been reported, but not systematically assessed. In a retrospective evaluation of 70 patients with Dravet syndrome and SCN1A mutations, seizures following vaccinations were reported in 27%. In 58% of these patients vaccination-related seizures represented the first clinical manifestation. The majority of seizures occurred after DPT vaccinations and within 72 h after vaccination. Two-thirds of events occurred in the context of fever. Our findings highlight seizures after vaccinations as a common feature in Dravet syndrome and emphasize the need for preventive measures for seizures triggered by vaccination or fever in these children.