Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population
Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population
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DOI：
10.1007/s00406-008-0813-z
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发表时间：
2008-06
影响因子：
4.7
通讯作者：
Yuichiro Watanabe;A. Nunokawa;M. Shibuya;N. Kaneko;H. Nawa;T. Someya
中科院分区：
文献类型：
--
作者：
Yuichiro Watanabe;A. Nunokawa;M. Shibuya;N. Kaneko;H. Nawa;T. Someya
白细胞介素2（IL-2）和IL-4是调节Th 1/Th 2平衡的多效性细胞因子，具有脑功能调节活性。因此，这些细胞因子与精神分裂症的病理生理学有关。最新的研究提供了关于这些细胞因子的遗传关联的有争议的结果。在德国人群中，IL 2 - 330 T/G和IL 4 - 590 C/T的功能多态性与精神分裂症相关，尽管在韩国人群中也报道了相互矛盾的结果。为了确定IL 2和IL 4是否与精神分裂症易感性有关，我们对日本受试者的7种多态性进行了一项中等规模的病例对照（536例患者和510例对照）关联研究。使用单标记或单倍型分析，这些基因与精神分裂症没有显着关联。本研究提示IL 2和IL 4与日本人群精神分裂症易感性无关。
Interleukin 2 (IL-2) and IL-4 are pleiotropic cytokines regulating Th1/Th2 balance and have a regulatory activity in brain function. Thus these cytokines have been implicated in the pathophysiology of schizophrenia. The latest studies provided controversial results regarding the genetic associations of these cytokines. The functional polymorphisms,IL2-330T/G andIL4-590C/T, were associated with schizophrenia in a German population, although contradictory findings were also reported in a Korean population. To ascertain whetherIL2andIL4contribute to vulnerability to schizophrenia, we conducted a moderate-scale case-control (536 patients and 510 controls) association study for seven polymorphisms in Japanese subjects. There were no significant associations of these genes with schizophrenia using either single marker or haplotype analyses. The present study suggests thatIL2andIL4do not contribute to vulnerability to schizophrenia in the Japanese population.