Direct-write assembly of silicate and borate bioactive glass scaffolds for bone repair
Direct-write assembly of silicate and borate bioactive glass scaffolds for bone repair
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DOI：
10.1016/j.jeurceramsoc.2012.05.005
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发表时间：
2012-11-01
影响因子：
5.7
通讯作者：
Rahaman, Mohamed N.
中科院分区：
文献类型：
--
作者：
Deliormanli, Aylin M.;Rahaman, Mohamed N.
通过有机溶剂悬浮液的机器人沉积（robocasting）制备了硅酸盐（13-93）和硼酸盐（13-93B3）生物活性玻璃支架，并对其在骨修复中的潜在应用进行了体外评估。对悬浮液（油墨）进行开发、表征并逐层沉积，形成网格状微观结构的三维支架（孔隙率接近50%，孔径420 +/- 30 μ m）。在压缩条件下测试了支架的力学响应，并评估了玻璃在模拟体液（SBF）中向羟基磷灰石（HA）样材料的转化。13-93支架的抗压强度为142 +/- 20 MPa，与人类皮质骨的强度相当，而13-93B3支架的抗压强度为65 +/- 11 MPa，远远高于骨小梁的抗压强度。浸泡在SBF中时，硼酸盐13-93B3支架比硅酸盐13-93支架转化为类ha材料的速度更快，但随着浸泡时间的延长，它们的强度下降幅度也更大。基于其较高的抗压强度和生物活性，本研究采用机器人铸造技术制备的支架在承重骨的修复中具有潜在的应用前景。(C) 2012 Elsevier Ltd.版权所有。
Silicate (13-93) and borate (13-93B3) bioactive glass scaffolds were created by robotic deposition (robocasting) of organic solvent-based suspensions and evaluated in vitro for potential application in bone repair. Suspensions (inks) were developed, characterized, and deposited layer-by-layer to form three-dimensional scaffolds with a grid-like microstructure (porosity approximate to 50%; pore width 420 +/- 30 mu m). The mechanical response of the scaffolds was tested in compression, and the conversion of the glass to hydroxyapatite (HA)-like material in a simulated body fluid (SBF) was evaluated. As fabricated, the 13-93 scaffolds had a compressive strength 142 +/- 20 MPa, comparable to the strength of human cortical bone, while the strength of the 13-93B3 scaffolds (65 +/- 11 MPa), was far higher than that for trabecular bone. When immersed in SBF, the borate 13-93B3 scaffolds converted faster than the silicate 13-93 scaffolds to an HA-like material, but they also showed a sharper decrease in strength with immersion time. Based on their high compressive strength and bioactivity, the scaffolds fabricated in this work by robocasting could have potential application in the repair of load-bearing bone. (C) 2012 Elsevier Ltd. All rights reserved.