μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
复制标题
DOI：
10.1006/exnr.2001.7727
复制
发表时间：
2001-09-01
影响因子：
5.3
通讯作者：
Brotchie, JM
中科院分区：
文献类型：
--
作者：
Henry, B;Fox, SH;Brotchie, JM
长期使用左旋多巴治疗帕金森病会出现不自主运动，称为左旋多巴诱导的运动障碍。据推测，纹状体输出通路中阿片类物质传递的增加可能是运动障碍产生的原因。在这项研究中，我们研究了阻断阿片肽传递对左旋多巴诱导的帕金森病灵长类动物模型-MPTP损伤的绒猴运动障碍的影响。非选择性和μ-或δ-亚型选择性阿片受体拮抗剂与左旋多巴联合给药导致运动障碍显著减少。左旋多巴的抗帕金森病作用没有减弱。这些数据表明，特定的μ-或δ-阿片受体拮抗剂可能适用于临床治疗左旋多巴诱导的帕金森病运动障碍。(C)北京：科学出版社.
Long-term treatment of Parkinson's disease with levodopa is complicated by the emergence of involuntary movements, known as levodopa-induced dyskinesia. It has been hypothesized that increased opioid transmission in striatal output pathways may be responsible for the generation of dyskinesia. In this study, we have investigated the effect of blockade of opioid peptide transmission on levodopa-induced dyskinesia in a primate model of Parkinson's disease-the MPTP-lesioned marmoset. Coadministration of nonselective and mu- or delta -subtype-selective opioid receptor antagonists with levodopa resulted in a significant decrease in dyskinesia. There was no attenuation of the anti-parkinsonian actions of levodopa. These data suggest that specific mu- or delta -opioid receptor antagonists might be applicable clinically in the treatment of levodopa-induced dyskinesia in Parkinson's disease. (C) 2001 Academic Press.