Ebola virus entry into host cells: identifying therapeutic strategies.
Ebola virus entry into host cells: identifying therapeutic strategies.
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DOI：
10.1007/s40588-015-0021-3
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发表时间：
2015-09
影响因子：
5.2
通讯作者：
Maury WJ
中科院分区：
文献类型：
--
作者：
Rhein BA;Maury WJ
丝状病毒在人类中引起严重的出血热。这一组的原型病毒，埃博拉病毒，负责目前在西非的丝状病毒流行。丝状病毒感染大多数哺乳动物细胞，导致广泛的物种嗜性，并可能有助于病毒在整个身体中的快速传播。深入了解丝状病毒进入事件将有助于开发针对病毒生命周期中这些关键步骤的治疗方法。本文综述了目前对丝状病毒进入的认识，并讨论了靶向进入的治疗策略的一些最新进展。
Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tropism and likely contributing to rapid spread of virus throughout the body. A thorough understanding of filovirus entry events will facilitate the development of therapeutics against these critical steps in the viral life cycle. This review summarizes the current understanding of filovirus entry and discusses some of the recent advancements in therapeutic strategies that target entry.