Kidney and breast cysts: a comparative study of fluids.
Kidney and breast cysts: a comparative study of fluids.
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肾脏和乳房囊肿：液体的比较研究。
DOI：
10.1159/000190292
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发表时间：
1997
期刊：
影响因子：
2.5
通讯作者：
Kenneth D. Gardner
中科院分区：
文献类型：
--
作者：
Davis K. Hurley;Steven M. Bandy;Robert H. Glew;Don M. Morris;Kenneth D. Gardner
在这项对常染色体显性遗传性多囊病（ADPKD）和乳腺大体囊性病（GCDB）囊肿中的液体进行的比较研究中，寻求氨基酸对囊肿液总体渗透活性的贡献。根据钠浓度分组的18名GCDB女性和8名ADPKD患者（n = 25）的液体（n = 18）通过常规方法分析钾、氯、蛋白质和渗透压摩尔浓度，并通过反相高压液相色谱法分析氨基酸。肾脏和乳腺囊肿液之间的相似性包括相对同渗压，广泛的钠浓度，钠和钾浓度之间的反比关系，低钠液体中氨基酸浓度较高，以及囊液中氨基酸浓度与血液及其某些成分之间的相关性。因此，ADPKD和GCDB的囊液具有共同的组成特征，并且可能来自血液蛋白的氨基酸在某些（特别是低钠）肾囊肿和乳腺囊肿中少量但具有显著的蓄积量。
The contributions of amino acids to the overall osmotic activity of cyst fluids were sought in this comparative study of fluids from the cysts of autosomal dominant polycystic disease (ADPKD) and gross cystic disease of the breast (GCDB). Fluids (n = 18) from 18 women with GCDB and from 8 patients with ADPKD (n = 25), grouped on the basis of sodium concentrations, were analyzed for potassium, chloride, protein, and osmolality by routine methods and for amino acids by reversed-phase high-pressure liquid chromatography. Similarities between kidney and breast cyst fluids included relative isosmolality, a wide range of sodium concentrations, an inverse relationship between sodium and potassium concentrations, higher concentrations of amino acids in low-sodium fluids, and significant correlations between sequential concentrations of amino acids in cyst fluids versus blood and some of its components. Therefore, cyst fluids in ADPKD and GCDB share compositional characteristics, and amino acids, possibly of blood protein origin, accumulate in small but osmotically significant amounts in some, particularly low-sodium, cysts of kidney and breast.