Neocortical propagation in temporal lobe spike foci on magnetoencephalography and electroencephalography.
Neocortical propagation in temporal lobe spike foci on magnetoencephalography and electroencephalography.
复制标题
脑磁图和脑电图上颞叶尖峰焦点的新皮质传播。
DOI：
10.1002/ana.410250409
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发表时间：
1989
影响因子：
11.2
通讯作者：
Barth,DS
中科院分区：
文献类型：
--
作者：
Sutherling,WW;Barth,DS
使用脑电图和脑磁图对 5 名颞叶复杂部分性癫痫患者的发作间期癫痫尖峰神经元群的传播进行了定量。在自发脑电图上，每位患者的尖峰复合体期间，蝶骨深部电极处有尖峰，头皮浅层电极处有尖峰。在每位患者中，蝶骨尖峰的峰值潜伏期与头皮尖峰不同，这与尖峰传播一致。脑电图用于触发蝶骨峰和头皮峰期间定型尖峰的两个脑磁图平均值。脑磁图区分了不同潜伏期的两个皮质尖峰群的中心，显示每位患者蝶骨触发的更深定位和头皮触发的更浅层定位（p<0.05）。尖峰的潜伏期差异和传播距离与皮质纤维的传导速度一致。对棘突皮质表面积的无创估计与通过颞叶新皮质的皮层电图描记法获得的估计一致。这些发现表明，在人类发作间期尖峰期间，颞叶深层和浅层皮层之间的神经元群可能通过单突触或寡突触途径进行传播。在复杂部分性癫痫中，这种发作间期系统似乎部分独立于海马发作间期系统。
Propagation of the neuronal population of the interictal epileptic spike was quantified in 5 patients with complex partial epilepsy arising from temporal lobe using electroencephalography and magnetoencephalography. During the spike complex in each patient there was a spike at the deep sphenoidal electrode and a spike at the superficial scalp electrode on spontaneous electroencephalography. In each patient the sphenoidal spike had a different peak latency than the scalp spike, consistent with spike propagation. Electroencephalography was used to trigger two magnetoencephalographic averages of stereotyped spikes during the sphenoidal peak and the scalp peak. Magnetoencephalography discriminated the centers of two cortical spike populations at different latencies, showing deeper localization with sphenoidal trigger and more superficial localization with scalp trigger in each patient (p< 0.05). Latency differences and propagation distances of spikes were consistent with the conduction velocity of corticocortical fibers. Noninvasive estimates of the cortical surface area of the spikes agreed with estimates obtained by electrocorticography over temporal neocortex. These findings indicate propagation of neuronal populations active during human interictal spikes between deep and superficial cortex of temporal lobe, likely by monosynaptic or oligosynaptic pathways. This interictal system appears to be partly independent of the hippocampal interictal system in complex partial epilepsy.