Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease
Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease
复制标题
DOI：
10.1111/j.1365-2265.2004.02136.x
复制
发表时间：
2004-11-01
影响因子：
3.2
通讯作者：
von Eckardstein, A
中科院分区：
文献类型：
--
作者：
Fischer, F;Schulte, H;von Eckardstein, A
目的胰岛素样生长因子及其结合蛋白（IGFBPs）是由心血管系统的细胞在全身和局部产生的。作为生长促进剂，它们可能在动脉粥样硬化中发挥作用。设计病例对照，横断面。患者共95例非糖尿病男性冠心病（CHD）患者和92例前瞻性心血管Munster（PROCAM）的先证者，年龄均在60岁以下，年龄匹配。体重指数（BMI）和吸烟习惯测量我们分析了血管造影评估的CHD存在与BMI的关联的强度和独立性，收缩压和舒张压，总胆固醇、高密度脂蛋白（HDL）和LDL胆固醇，甘油三酯，脂蛋白（a），载脂蛋白A-I和B，总IGF-I和游离IGF-II，IGFBP-1，IGFBP-3，IGFBP-5，酸不稳定亚基（ALS），胰岛素，C-肽，睾酮，DHEAS和性激素结合球蛋白。结果使用多变量统计分析，CHD的存在与总IGF-I、IGFBP-5、ALS和IGFBP-3呈显著正相关。这些协会是相互独立的，以及传统的危险因素，胰岛素和性hormones.CONCLUSION这些观察可能表明GH/IGF轴在冠状动脉粥样硬化的发病作用。
OBJECTIVE IGFs and their binding proteins (IGFBPs) are produced both systemically and locally by cells of the cardiovascular system. As growth promoters, they may play a role in atherosclerosis.DESIGN Case-control, cross-sectional.PATIENTS A total of 95 nondiabetic male patients with coronary heart disease (CHD) and 92 probands from the Prospective Cardiovascular Munster (PROCAM) who were below the age of 60 years and matched by age, body mass index (BMI) and smoking habitsMEASUREMENTS We analysed the strength and independence of associations of angiographically assessed presence of CHD with BMI, systolic and diastolic blood pressure, total, high-density lipoprotein (HDL) and LDL cholesterol, triglycerides, lipoprotein(a), apolipoproteins A-I and B, total and free IGF-I, IGF-II, IGFBP-1, IGFBP-3, IGFBP-5, acid-labile subunit (ALS), insulin, C-peptide, testosterone, DHEAS and sex hormone binding globulin.RESULTS Using multivariate statistical analysis, the presence of CHD had significant positive associations with total IGF-I, IGFBP-5, ALS and IGFBP-3. These associations were independent of each other as well as of traditional risk factors, insulin and sex hormones.CONCLUSION These observations may indicate a pathogenetic role of the GH/IGF axis in coronary atherosclerosis.