Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1
Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1
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DOI：
10.1016/j.bbrc.2014.01.039
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发表时间：
2014-02-28
影响因子：
3.1
通讯作者：
Kawabata, Jun
中科院分区：
文献类型：
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作者：
Kimura, Taro;Kato, Eisuke;Kawabata, Jun
糖尿病是一种全球性疾病，其患者人数正在增加。在用于治疗的各种药剂中，直接作用于肌肉的那些药剂目前正引起注意，因为肌肉是人体的主要组织之一，并且在II型糖尿病中其代谢降低。在这项研究中，我们发现，羟胺（HA）增强葡萄糖摄取C2C12肌管。对HA作用机制的分析表明，胰岛素信号通路中的IRS1、PI3 K和Akt参与了HA的作用。进一步研究HA对胰岛素受体或IRS 1的激活机制，可能为开发替代胰岛素的新型抗糖尿病药物提供思路。(C)2014爱思唯尔公司All rights reserved.
Diabetes mellitus is a global disease, and the number of patients with it is increasing. Of various agents for treatment, those that directly act on muscle are currently attracting attention because muscle is one of the main tissues in the human body, and its metabolism is decreased in type II diabetes. In this study, we found that hydroxylamine (HA) enhances glucose uptake in C2C12 myotubes. Analysis of HA's mechanism revealed the involvement of IRS1, PI3 K and Akt that is related to the insulin signaling pathway. Further investigation about the activation mechanism of insulin receptor or IRS1 by HA may provide a way to develop a novel anti-diabetic agent alternating to insulin. (C) 2014 Elsevier Inc. All rights reserved.