ADVANCED GRANDMATERNAL AGE ON THE MOTHERS SIDE - A RISK OF GIVING RISE TO TRISOMY-21
ADVANCED GRANDMATERNAL AGE ON THE MOTHERS SIDE - A RISK OF GIVING RISE TO TRISOMY-21
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DOI：
10.1111/j.1469-1809.1984.tb00843.x
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发表时间：
1984-01-01
影响因子：
1.9
通讯作者：
MIKKELSEN, M
中科院分区：
文献类型：
--
作者：
AAGESEN, L;GRINSTED, J;MIKKELSEN, M
唐氏综合征患儿外祖母的年龄分布与同组的祖父母和健康儿童的祖父母（对照组）进行了比较。显着先进的外祖母的年龄被发现在唐氏综合征的情况下所造成的第一次减数分裂错误的母亲卵子发生。发现高龄产妇的外祖母年龄与产妇年龄无关。唐氏综合症患者和对照组祖父的年龄没有差异。
The age distribution of maternal grandmothers of children with Down syndrome was compared with paternal grandparents of the same group and with grandparents of healthy children (controls). The significant advanced maternal grandmaternal age was found in cases of Down syndrome caused by first meiotic error in the maternal oogenesis. The advanced maternal grandmaternal age was found independent of maternal age. No differences were found between the ages of grandfathers of Down syndrome and of controls.