IMMUNOLOGICAL CHARACTERISTICS OF NY STRAINS OF INFLUENZA-A VIRUS FROM THE 1957 PANDEMIC
IMMUNOLOGICAL CHARACTERISTICS OF NY STRAINS OF INFLUENZA-A VIRUS FROM THE 1957 PANDEMIC
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DOI：
10.3181/00379727-98-24092
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发表时间：
1958-01-01
影响因子：
--
通讯作者：
TAMM, I
中科院分区：
文献类型：
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作者：
CHOPPIN, PW;OSTERHOUT, S;TAMM, I
1957年大流行期间，在纽约分离出六种甲型流感病毒株。与2株远东分离株的抗原关系密切，与较老的原型株也有轻微的抗原关系。其中一个本地分离株RI/5/57是人血清中存在抗1957年甲型流感病毒株的血凝抑制和中和抗体的非常敏感的指标。从1940年到1957年，在不同年龄的患者中证实了R1/5/57菌株的抗体。6个纽约菌株对血凝的非特异性抑制剂的敏感性从3个菌株的明显不敏感性到2个菌株的极端敏感性不等。
Six strains of influenza A virus were isolated in New York during the 1957 pandemic. Close antigenic relationship was found among these strains and 2 Far East isolates, and slight antigenic relationship to older prototype strains was also demonstrated. One of the local isolates, RI/5/57, was a very sensitive indicator of the presence of hemagglutination-inhibiting and neutralizing antibodies against the 1957 strains of influenza A virus in human serum. Antibodies to the Rl/5/57 strain were demonstrated in patients of various ages obtained from 1940 to 1957 The sensitivity of the 6 New York strains to non-specific inhibitors of hemagglutination varied from apparent insensitivity in 3 strains to extreme sensitivity in 2.