Pediatric precision oncology: "better three hours too soon than a minute too late".
Pediatric precision oncology: "better three hours too soon than a minute too late".
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DOI：
10.3389/fonc.2023.1279953
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发表时间：
2023
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
精确肿瘤学的定义是根据患者肿瘤的基因组图谱为癌症患者选择有效的治疗方法，以确定有针对性的改变。精确肿瘤学在儿童癌症患者中的应用进展慢于成人，但正在获得势头。过去十年为成人癌症适应症开发的临床和制药进展已开始进入儿科肿瘤学，为年轻的高危和难治性患者扩大了治疗选择。因此，FDA已经批准了23种用于儿童癌症适应症的靶向药物，将靶向药物纳入护理标准。我们的精确肿瘤学项目是在一家中等规模的儿童医院，缺乏内部测序能力和生物信息学。我们已经开发了方法、医疗和商业合作伙伴关系，为我们的患者提供最先进的肿瘤特征和有针对性的治疗选择。我们在这里提出了一种简化和实用的方案，旨在使任何肿瘤学家为他们的患者实施精确的肿瘤学选择。
Precision oncology is defined as the selection of an effective treatment for a cancer patient based upon genomic profiling of the patient’s tumor to identify targetable alterations. The application of precision oncology toward pediatric cancer patients has moved forward more slowly than with adults but is gaining momentum. Clinical and pharmaceutical advances developed over the past decade for adult cancer indications have begun to move into pediatric oncology, expanding treatment options for young high-risk and refractory patients. As a result, the FDA has approved 23 targeted drugs for pediatric cancer indications, moving targeted drugs into the standard of care. Our precision oncology program is in a medium sized children’s hospital, lacking internal sequencing capabilities and bioinformatics. We have developed methods, medical and business partnerships to provide state-of-the-art tumor characterization and targeted treatment options for our patients. We present here a streamlined and practical protocol designed to enable any oncologist to implement precision oncology options for their patients.
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影响因子：
28.4
作者：
Lupo, Philip J.;Schraw, Jeremy M.;Plon, Sharon E.
通讯作者：
Plon, Sharon E.
影响因子：
14.5
作者：
Tsimberidou, Apostolia M.;Fountzilas, Elena;Kurzrock, Razelle
通讯作者：
Kurzrock, Razelle
DOI：
10.1200/jco.20.03060
发表时间：
2021-09-10
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Shern JF;Selfe J;Izquierdo E;Patidar R;Chou HC;Song YK;Yohe ME;Sindiri S;Wei J;Wen X;Rudzinski ER;Barkauskas DA;Lo T;Hall D;Linardic CM;Hughes D;Jamal S;Jenney M;Chisholm J;Brown R;Jones K;Hicks B;Angelini P;George S;Chesler L;Hubank M;Kelsey A;Gatz SA;Skapek SX;Hawkins DS;Shipley JM;Khan J
通讯作者：
Khan J
影响因子：
30.8
作者：
Dharia NV;Kugener G;Guenther LM;Malone CF;Durbin AD;Hong AL;Howard TP;Bandopadhayay P;Wechsler CS;Fung I;Warren AC;Dempster JM;Krill-Burger JM;Paolella BR;Moh P;Jha N;Tang A;Montgomery P;Boehm JS;Hahn WC;Roberts CWM;McFarland JM;Tsherniak A;Golub TR;Vazquez F;Stegmaier K
通讯作者：
Stegmaier K
影响因子：
64.8
作者：
Ma X;Liu Y;Liu Y;Alexandrov LB;Edmonson MN;Gawad C;Zhou X;Li Y;Rusch MC;Easton J;Huether R;Gonzalez-Pena V;Wilkinson MR;Hermida LC;Davis S;Sioson E;Pounds S;Cao X;Ries RE;Wang Z;Chen X;Dong L;Diskin SJ;Smith MA;Guidry Auvil JM;Meltzer PS;Lau CC;Perlman EJ;Maris JM;Meshinchi S;Hunger SP;Gerhard DS;Zhang J
通讯作者：
Zhang J