The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia
The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia
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DOI：
10.1111/j.1365-2141.2007.06779.x
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发表时间：
2007-10-01
影响因子：
6.5
通讯作者：
Carcassi, Carlo
中科院分区：
文献类型：
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作者：
La Nasa, Giorgio;Littera, Roberto;Carcassi, Carlo
人类白细胞抗原（HLA）-G基因（HLA-G）的14-bp插入多态性的存在通过增加HLA-G分子的合成促进免疫耐受。我们在一个由53名从无关供体移植的地中海贫血患者组成的大型队列中调查了这种多态性。16名14 bp缺失纯合子患者（30.2%）发生急性移植物抗宿主病（aGvHD）的风险高于14 bp插入纯合子患者（-14-bp/-14-bp vs +14-bp/+14-bp：相对风险= 15.0; 95%置信区间1.59-141.24; P = 0.008）。因此，14 bp多态性可能是骨髓移植后aGvHD的一个重要预测因子。
The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.