Radiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement
Radiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement
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DOI：
10.1007/s00330-015-3812-2
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发表时间：
2016-01-01
影响因子：
5.9
通讯作者：
Lin, MingDe
中科院分区：
文献类型：
--
作者：
Chockalingam, Arun;Duran, Rafael;Lin, MingDe
探讨兴趣区（ROI）放置对经导管动脉化疗栓塞（TACE）治疗的肝细胞癌（HCC）患者三维肿瘤增强的影响[定量欧洲肝脏研究协会（qEASL）]。一期：40例HCC患者有9个roi，由一个阅读器使用系统技术放置（3个同侧病变，3个对侧病变，3个分散在整个肝脏），并测量qEASL方差。计算类内相关性。二期：选择15例肝细胞癌组织分割患者。通过AC系统放置6个roi（3个roi同侧，3个roi对侧病变）。2名放射科医生放置了3个roi。通过Pearson相关、线性回归和中位差将qEASL值与组织病理学值进行比较。阶段1：分散的方法（在阶段2中被抛弃）具有低一致性和高方差。第2阶段：qEASL在系统方法[Pearson相关系数= 0.886（同侧）和0.727（对侧）]和临床方法（0.625和0.879）中与病理有较强的相关性。然而，同侧放置与病理最匹配（中位数差：5.4%；相关性：0.89；回归CI:[0.904, 0.1409]）。qEASL是一种鲁棒的方法，在测试位置之间具有可比性。同侧放置具有较高的一致性和较好的病理相关性。同侧和对侧ROI放置产生高一致性和低方差。两种ROI放置方法产生的qEASL值与组织病理学密切相关。同侧ROI放置与病理相关性最好，一致性高。
To investigate the influence of region-of-interest (ROI) placement on 3D tumour enhancement [Quantitative European Association for the Study of the Liver (qEASL)] in hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE).Phase 1: 40 HCC patients had nine ROIs placed by one reader using systematic techniques (3 ipsilateral to the lesion, 3 contralateral to the lesion, and 3 dispersed throughout the liver) and qEASL variance was measured. Intra-class correlations were computed. Phase 2: 15 HCC patients with histosegmentation were selected. Six ROIs were systematically placed by AC (3 ROIs ipsilateral and 3 ROIs contralateral to the lesion). Three ROIs were placed by 2 radiologists. qEASL values were compared to histopathology by Pearson's correlation, linear regression, and median difference.Phase 1: The dispersed method (abandoned in phase 2) had low consistency and high variance. Phase 2: qEASL correlated strongly with pathology in systematic methods [Pearson's correlation coefficient = 0.886 (ipsilateral) and 0.727 (contralateral)] and in clinical methods (0.625 and 0.879). However, ipsilateral placement matched best with pathology (median difference: 5.4 %; correlation: 0.89; regression CI: [0.904, 0.1409]).qEASL is a robust method with comparable values among tested placements. Ipsilateral placement showed high consistency and better pathological correlation.aEuro cent Ipsilateral and contralateral ROI placement produces high consistency and low variance.aEuro cent Both ROI placement methods produce qEASL values that correlate well with histopathology.aEuro cent Ipsilateral ROI placement produces best correlation to pathology along with high consistency.